Trichoderins, novel aminolipopeptides from a marine sponge-derived Trichoderma sp., are active against dormant mycobacteria

Patamaporn Pruksakorn; Masayoshi Arai; Naoyuki Kotoku; Catherine Vilchze; Anthony D. Baughn; Prashini Moodley; William R. Jacobs; Motomasa Kobayashi

doi:10.1016/j.bmcl.2010.04.100

Trichoderins, novel aminolipopeptides from a marine sponge-derived Trichoderma sp., are active against dormant mycobacteria

Patamaporn Pruksakorn, Masayoshi Arai, Naoyuki Kotoku, Catherine Vilchze, Anthony D. Baughn, Prashini Moodley, William R. Jacobs, Motomasa Kobayashi

Microbiology & Immunology

Research output: Contribution to journal › Article › peer-review

142 Scopus citations

Abstract

Three new aminolipopeptides, designated trichoderins A (1), A1 (2), and B (3), were isolated from a culture of marine sponge-derived fungus of Trichoderma sp. as anti-mycobacterial substances with activity against active and dormant bacilli. The chemical structures of trichoderins were determined on the basis of spectroscopic study. Trichoderins showed potent anti-mycobacterial activity against Mycobacterium smegmatis, Mycobacterium bovis BCG, and Mycobacterium tuberculosis H37Rv under standard aerobic growth conditions as well as dormancy-inducing hypoxic conditions, with MIC values in the range of 0.02-2.0 μg/mL.

Original language	English (US)
Pages (from-to)	3658-3663
Number of pages	6
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	20
Issue number	12
DOIs	https://doi.org/10.1016/j.bmcl.2010.04.100
State	Published - 2010

Keywords

Aminolipopeptide
Anti-mycobacterial activity
Dormant
Trichoderin
Trichoderma sp.
Tuberculosis

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.bmcl.2010.04.100

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title = "Trichoderins, novel aminolipopeptides from a marine sponge-derived Trichoderma sp., are active against dormant mycobacteria",

abstract = "Three new aminolipopeptides, designated trichoderins A (1), A1 (2), and B (3), were isolated from a culture of marine sponge-derived fungus of Trichoderma sp. as anti-mycobacterial substances with activity against active and dormant bacilli. The chemical structures of trichoderins were determined on the basis of spectroscopic study. Trichoderins showed potent anti-mycobacterial activity against Mycobacterium smegmatis, Mycobacterium bovis BCG, and Mycobacterium tuberculosis H37Rv under standard aerobic growth conditions as well as dormancy-inducing hypoxic conditions, with MIC values in the range of 0.02-2.0 μg/mL.",

keywords = "Aminolipopeptide, Anti-mycobacterial activity, Dormant, Trichoderin, Trichoderma sp., Tuberculosis",

author = "Patamaporn Pruksakorn and Masayoshi Arai and Naoyuki Kotoku and Catherine Vilchze and Baughn, {Anthony D.} and Prashini Moodley and Jacobs, {William R.} and Motomasa Kobayashi",

note = "Funding Information: The authors thank Ms. Salona Moodley, Mr. Yushir R. Maharaj, Ms. Karnishree Govender (University of KwaZulu Natal) for excellent technical assistance. A.D.B. was supported by a Grant from the Helen Hay Whitney Foundation . This study was financially supported by the Hoh-ansha Foundation , the Uehara Memorial Foundation , JSPS-South Africa (NRF) Joint Research Program , and Grant-in-Aid for scientific research from the Ministry of Education, Culture, Sports, Science and Technology of Japan .",

year = "2010",

doi = "10.1016/j.bmcl.2010.04.100",

language = "English (US)",

volume = "20",

pages = "3658--3663",

journal = "Bioorganic and Medicinal Chemistry Letters",

issn = "0960-894X",

publisher = "Elsevier Limited",

number = "12",

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TY - JOUR

T1 - Trichoderins, novel aminolipopeptides from a marine sponge-derived Trichoderma sp., are active against dormant mycobacteria

AU - Pruksakorn, Patamaporn

AU - Arai, Masayoshi

AU - Kotoku, Naoyuki

AU - Vilchze, Catherine

AU - Baughn, Anthony D.

AU - Moodley, Prashini

AU - Jacobs, William R.

AU - Kobayashi, Motomasa

N1 - Funding Information: The authors thank Ms. Salona Moodley, Mr. Yushir R. Maharaj, Ms. Karnishree Govender (University of KwaZulu Natal) for excellent technical assistance. A.D.B. was supported by a Grant from the Helen Hay Whitney Foundation . This study was financially supported by the Hoh-ansha Foundation , the Uehara Memorial Foundation , JSPS-South Africa (NRF) Joint Research Program , and Grant-in-Aid for scientific research from the Ministry of Education, Culture, Sports, Science and Technology of Japan .

PY - 2010

Y1 - 2010

N2 - Three new aminolipopeptides, designated trichoderins A (1), A1 (2), and B (3), were isolated from a culture of marine sponge-derived fungus of Trichoderma sp. as anti-mycobacterial substances with activity against active and dormant bacilli. The chemical structures of trichoderins were determined on the basis of spectroscopic study. Trichoderins showed potent anti-mycobacterial activity against Mycobacterium smegmatis, Mycobacterium bovis BCG, and Mycobacterium tuberculosis H37Rv under standard aerobic growth conditions as well as dormancy-inducing hypoxic conditions, with MIC values in the range of 0.02-2.0 μg/mL.

AB - Three new aminolipopeptides, designated trichoderins A (1), A1 (2), and B (3), were isolated from a culture of marine sponge-derived fungus of Trichoderma sp. as anti-mycobacterial substances with activity against active and dormant bacilli. The chemical structures of trichoderins were determined on the basis of spectroscopic study. Trichoderins showed potent anti-mycobacterial activity against Mycobacterium smegmatis, Mycobacterium bovis BCG, and Mycobacterium tuberculosis H37Rv under standard aerobic growth conditions as well as dormancy-inducing hypoxic conditions, with MIC values in the range of 0.02-2.0 μg/mL.

KW - Aminolipopeptide

KW - Anti-mycobacterial activity

KW - Dormant

KW - Trichoderin

KW - Trichoderma sp.

KW - Tuberculosis

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Trichoderins, novel aminolipopeptides from a marine sponge-derived Trichoderma sp., are active against dormant mycobacteria

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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