TY - JOUR
T1 - Trial of antihypertensive intervention and management
T2 - Greater efficacy with weight reduction than with a sodium-potassium intervention
AU - Wylie-Rosett, Judith
AU - Wassertheil-Smoller, Sylvia
AU - Blaufox, M. Donald
AU - Davis, Barry R.
AU - Langford, Herbert G.
AU - Oberman, Albert
AU - Jennings, Stephanie
AU - Hataway, Heidi
AU - Stern, Judith
AU - Zimbaldi, Neal
N1 - Funding Information:
Research upon which the article is based was performed pursuant to grant No. R01-HL-30101-10A with the National Heart, Lung, and Blood Institute, National Institutes of Health, US Department of Health and Human Resources.
PY - 1993/4
Y1 - 1993/4
N2 - The Trial of Antihypertensive Intervention and Management evaluated nine diet-drug combinations in 878 mildly hypertensive, moderately obese participants using a 3 × 3 factorial design. Drugs evaluated were placebo, diuretic (chlorthalidone), and β-blocker (atenolol); diets were usual (no intervention), weight reduction, and low sodium/high potassium ( Na K). This article reports 6-month dietary changes and the effect of dietary change on blood pressure. Six-month mean weight change was -4.7 kg in the weight reduction group, -0.3 kg in the Na K group, and -0.5 kg in the usual-diet group. At 6 months, daily electrolyte excretion had changed in the Na K intervention group. Daily sodium excretion decreased from 138.0 to 112.0 mmol in the Na K group and increased from 134.1 to 138.4 mmol in the weight reduction group and from 129.1 to 137.0 mmol in the usual-diet group. Daily potassium output increased from 58.7 to 71.4 mmol in the Na K group, from 57.0 to 60.5 mmol in the weight reduction group, and from 55.3 to 59.1 mmol in the usual diet group. Analysis of 3-day food records indicated that sodium intake decreased from 141.1 to 85.8 mmol and potassium intake increased from 76.4 to 90.5 mmol. Our results indicate that the goal for weight reduction was more easily achieved than the goal for electrolyte modification.
AB - The Trial of Antihypertensive Intervention and Management evaluated nine diet-drug combinations in 878 mildly hypertensive, moderately obese participants using a 3 × 3 factorial design. Drugs evaluated were placebo, diuretic (chlorthalidone), and β-blocker (atenolol); diets were usual (no intervention), weight reduction, and low sodium/high potassium ( Na K). This article reports 6-month dietary changes and the effect of dietary change on blood pressure. Six-month mean weight change was -4.7 kg in the weight reduction group, -0.3 kg in the Na K group, and -0.5 kg in the usual-diet group. At 6 months, daily electrolyte excretion had changed in the Na K intervention group. Daily sodium excretion decreased from 138.0 to 112.0 mmol in the Na K group and increased from 134.1 to 138.4 mmol in the weight reduction group and from 129.1 to 137.0 mmol in the usual-diet group. Daily potassium output increased from 58.7 to 71.4 mmol in the Na K group, from 57.0 to 60.5 mmol in the weight reduction group, and from 55.3 to 59.1 mmol in the usual diet group. Analysis of 3-day food records indicated that sodium intake decreased from 141.1 to 85.8 mmol and potassium intake increased from 76.4 to 90.5 mmol. Our results indicate that the goal for weight reduction was more easily achieved than the goal for electrolyte modification.
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U2 - 10.1016/0002-8223(93)92286-7
DO - 10.1016/0002-8223(93)92286-7
M3 - Article
C2 - 8454808
AN - SCOPUS:0027417172
SN - 0002-8223
VL - 93
SP - 408
EP - 415
JO - Journal of the American Dietetic Association
JF - Journal of the American Dietetic Association
IS - 4
ER -