Treatment outcome in depressed latinos predicted by concomitant psychosislike symptoms

Paolo Cassano, Nhi Ha Trinh, Trina Chang, Cristina Cusin, Lauren Fisher, Paola Pedrelli, Maren Nyer, Daniel Ju Hyung Kim, Jonathan Alpert, David Mischoulon

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


We compared treatment response (≥50 decrease in Nine-ItemPatient Health Questionnaire total score) among 24 Latinos with major depressive disorder, presenting with and without specific psychosislike symptoms: A, hearing noises or house sounds, B, hearing voices calling one's name, C, seeing fleeting visions such as shadows, and D, symptoms more likely to be truly psychotic (e.g., poorly defined and short-lasting voices [other than B], fleeting paranoid ideation, or fleeting ideas of reference). 18 subjects (75%) endorsed symptoms of cluster A, 12 (50%) of cluster B, 10 (31%) of cluster C, and 12 (50%) of cluster D. Only subjects who reported symptoms from the D cluster exhibited significantly unfavorable depressive outcomes (compared to those with absence of D symptoms). The authors propose a phenomenological differentiation between benign psychosislike symptoms (clusters A-C) and the expression of the psychotic continuum (cluster D) in depressed Latinos.

Original languageEnglish (US)
Pages (from-to)769-773
Number of pages5
JournalJournal of Nervous and Mental Disease
Issue number10
StatePublished - 2015
Externally publishedYes


  • Antipsychotic augmentation
  • Latinos
  • Major depressive disorder
  • Psychosislike symptoms
  • Psychotic spectrum
  • Subthreshold psychosis

ASJC Scopus subject areas

  • Psychiatry and Mental health


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