TY - JOUR
T1 - Treatment of metabolic acidosis in patients with CKD
AU - Chen, Wei
AU - Abramowitz, Matthew K.
N1 - Funding Information:
Support: This research was supported by Clinical and Translational Science Award (CTSA) grants UL1RR025750 , KL2RR025749 , and TL1RR025748 from the National Center for Research Resources , a component of the National Institutes of Health (NIH) , and by the National Center for Advancing Translational Sciences , a component of the NIH, through CTSA grants UL1TR000086 , TL1RR000087 , and KL2TR000088 .
PY - 2014/2
Y1 - 2014/2
N2 - Metabolic acidosis is a common complication of chronic kidney disease and is believed to contribute to a number of sequelae, including bone disease, altered protein metabolism, skeletal muscle wasting, and progressive glomerular filtration rate loss. Small trials in animal models and humans suggest a role for alkali therapy to lessen these complications. Recent studies support this notion, although more definitive evidence is needed on the long-term benefits of alkali therapy and the optimal serum bicarbonate level. The role of dietary modification also should be given greater consideration. In addition, potential adverse effects of alkali treatment must be taken into consideration, including sodium retention and the theoretical concern of promoting vascular calcification. This teaching case summarizes the rationale for and benefits and complications of base therapy in patients with chronic kidney disease.
AB - Metabolic acidosis is a common complication of chronic kidney disease and is believed to contribute to a number of sequelae, including bone disease, altered protein metabolism, skeletal muscle wasting, and progressive glomerular filtration rate loss. Small trials in animal models and humans suggest a role for alkali therapy to lessen these complications. Recent studies support this notion, although more definitive evidence is needed on the long-term benefits of alkali therapy and the optimal serum bicarbonate level. The role of dietary modification also should be given greater consideration. In addition, potential adverse effects of alkali treatment must be taken into consideration, including sodium retention and the theoretical concern of promoting vascular calcification. This teaching case summarizes the rationale for and benefits and complications of base therapy in patients with chronic kidney disease.
KW - Metabolic acidosis
KW - alkali therapy
KW - bicarbonate
KW - chronic kidney disease
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U2 - 10.1053/j.ajkd.2013.06.017
DO - 10.1053/j.ajkd.2013.06.017
M3 - Article
C2 - 23932089
AN - SCOPUS:84892921362
SN - 0272-6386
VL - 63
SP - 311
EP - 317
JO - American Journal of Kidney Diseases
JF - American Journal of Kidney Diseases
IS - 2
ER -