Treatment of metabolic acidosis in patients with CKD

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28 Scopus citations


Metabolic acidosis is a common complication of chronic kidney disease and is believed to contribute to a number of sequelae, including bone disease, altered protein metabolism, skeletal muscle wasting, and progressive glomerular filtration rate loss. Small trials in animal models and humans suggest a role for alkali therapy to lessen these complications. Recent studies support this notion, although more definitive evidence is needed on the long-term benefits of alkali therapy and the optimal serum bicarbonate level. The role of dietary modification also should be given greater consideration. In addition, potential adverse effects of alkali treatment must be taken into consideration, including sodium retention and the theoretical concern of promoting vascular calcification. This teaching case summarizes the rationale for and benefits and complications of base therapy in patients with chronic kidney disease.

Original languageEnglish (US)
Pages (from-to)311-317
Number of pages7
JournalAmerican Journal of Kidney Diseases
Issue number2
StatePublished - Feb 2014


  • Metabolic acidosis
  • alkali therapy
  • bicarbonate
  • chronic kidney disease

ASJC Scopus subject areas

  • Nephrology


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