Treatment of Chronic Hepatitis C in Patients Receiving Opioid Agonist Therapy: A Review of Best Practice

Brianna L. Norton; Matthew J. Akiyama; Philippe J. Zamor; Alain H. Litwin

doi:10.1016/j.idc.2018.02.001

Treatment of Chronic Hepatitis C in Patients Receiving Opioid Agonist Therapy: A Review of Best Practice

Brianna L. Norton, Matthew J. Akiyama, Philippe J. Zamor, Alain H. Litwin

Medicine

Research output: Contribution to journal › Review article › peer-review

23 Scopus citations

Abstract

Injection drug use is the most common transmission route for hepatitis C. High rates of infection are observed among individuals on opioid agonist therapy. Although people who inject drugs carry the highest burden, few have initiated treatment. We present a comprehensive review of the evidence on the efficacy of HCV medications, drug–drug interactions, and barriers to and models of care. Studies have demonstrated comparable efficacy for individuals who are on opioid agonist therapy compared with those who are not. We propose that a strategy of treatment and cure-as-prevention is imperative in this population to curb the hepatitis C epidemic.

Original language	English (US)
Pages (from-to)	347-370
Number of pages	24
Journal	Infectious disease clinics of North America
Volume	32
Issue number	2
DOIs	https://doi.org/10.1016/j.idc.2018.02.001
State	Published - Jun 2018

Keywords

Best practice
Direct acting antivirals
Drug-drug interactions
Hepatitis C virus
Opioid agonist therapy

ASJC Scopus subject areas

Microbiology (medical)
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.idc.2018.02.001

Cite this

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title = "Treatment of Chronic Hepatitis C in Patients Receiving Opioid Agonist Therapy: A Review of Best Practice",

abstract = "Injection drug use is the most common transmission route for hepatitis C. High rates of infection are observed among individuals on opioid agonist therapy. Although people who inject drugs carry the highest burden, few have initiated treatment. We present a comprehensive review of the evidence on the efficacy of HCV medications, drug–drug interactions, and barriers to and models of care. Studies have demonstrated comparable efficacy for individuals who are on opioid agonist therapy compared with those who are not. We propose that a strategy of treatment and cure-as-prevention is imperative in this population to curb the hepatitis C epidemic.",

keywords = "Best practice, Direct acting antivirals, Drug-drug interactions, Hepatitis C virus, Opioid agonist therapy",

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T1 - Treatment of Chronic Hepatitis C in Patients Receiving Opioid Agonist Therapy

T2 - A Review of Best Practice

AU - Norton, Brianna L.

AU - Akiyama, Matthew J.

AU - Zamor, Philippe J.

AU - Litwin, Alain H.

PY - 2018/6

Y1 - 2018/6

N2 - Injection drug use is the most common transmission route for hepatitis C. High rates of infection are observed among individuals on opioid agonist therapy. Although people who inject drugs carry the highest burden, few have initiated treatment. We present a comprehensive review of the evidence on the efficacy of HCV medications, drug–drug interactions, and barriers to and models of care. Studies have demonstrated comparable efficacy for individuals who are on opioid agonist therapy compared with those who are not. We propose that a strategy of treatment and cure-as-prevention is imperative in this population to curb the hepatitis C epidemic.

AB - Injection drug use is the most common transmission route for hepatitis C. High rates of infection are observed among individuals on opioid agonist therapy. Although people who inject drugs carry the highest burden, few have initiated treatment. We present a comprehensive review of the evidence on the efficacy of HCV medications, drug–drug interactions, and barriers to and models of care. Studies have demonstrated comparable efficacy for individuals who are on opioid agonist therapy compared with those who are not. We propose that a strategy of treatment and cure-as-prevention is imperative in this population to curb the hepatitis C epidemic.

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KW - Direct acting antivirals

KW - Drug-drug interactions

KW - Hepatitis C virus

KW - Opioid agonist therapy

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Treatment of Chronic Hepatitis C in Patients Receiving Opioid Agonist Therapy: A Review of Best Practice

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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