Treatment of AIDS-related lymphomas

J. A. Sparano

Research output: Contribution to journalReview articlepeer-review

17 Scopus citations


Infection with HIV is associated with an increased risk of systemic and primary central nervous system non-Hodgkin's lymphoma. Patients with systemic non-Hodgkin's lymphoma usually present with high- or intermediate-grade histology and extranodal dissemination. Although the prognosis for such patients is poor, some patients clearly benefit from combination chemotherapy, and several new treatment approaches appear promising. Primary central nervous system lymphoma usually occurs in patients with more profound immunosuppression and is associated with a dismal prognosis. Selected patients with good performance status may benefit from therapy, particularly if opportunistic infections have been few and nondebilitating. Finally, Hodgkin's disease has been reported in patients with HIV infection, particularly in patients with a history of intravenous drug use, and it is more likely to present with advanced-stage disease and unfavorable histology.

Original languageEnglish (US)
Pages (from-to)442-449
Number of pages8
JournalCurrent Opinion in Oncology
Issue number5
StatePublished - Jan 1 1995

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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