Translational veterinary epilepsy: A win-win situation for human and veterinary neurology

Marios Charalambous, Andrea Fischer, Heidrun Potschka, Matthew C. Walker, Robrecht Raedt, Kristl Vonck, Paul Boon, Hannes Lohi, Wolfgang Löscher, Gregory Worrell, Tosso Leeb, Andrew McEvoy, Pasquale Striano, Gerhard Kluger, Aristea S. Galanopoulou, Holger A. Volk, Sofie F.M. Bhatti

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Epilepsy is a challenging multifactorial disorder with a complex genetic background. Our current understanding of the pathophysiology and treatment of epilepsy has substantially increased due to animal model studies, including canine studies, but additional basic and clinical research is required. Drug-resistant epilepsy is an important problem in both dogs and humans, since seizure freedom is not achieved with the available antiseizure medications. The evaluation and exploration of pharmacological and particularly non-pharmacological therapeutic options need to remain a priority in epilepsy research. Combined efforts and sharing knowledge and expertise between human medical and veterinary neurologists are important for improving the treatment outcomes or even curing epilepsy in dogs. Such interactions could offer an exciting approach to translate the knowledge gained from people and rodents to dogs and vice versa. In this article, a panel of experts discusses the similarities and knowledge gaps in human and animal epileptology, with the aim of establishing a common framework and the basis for future translational epilepsy research.

Original languageEnglish (US)
Article number105956
JournalVeterinary Journal
StatePublished - Mar 2023


  • Dog
  • Human
  • Nervous system
  • Seizures
  • Therapy

ASJC Scopus subject areas

  • Animal Science and Zoology
  • veterinary(all)


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