Transepidermal water loss in the orphan forms of ichthyosis

Taylor R. Erickson; Morgan B. Murphrey; Hajar Abu-Zayed; Benedict Wu; Erin Ibler; Stephanie M. Rangel; Amy S. Paller

doi:10.1111/pde.14221

Transepidermal water loss in the orphan forms of ichthyosis

Taylor R. Erickson, Morgan B. Murphrey, Hajar Abu-Zayed, Benedict Wu, Erin Ibler, Stephanie M. Rangel, Amy S. Paller

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

As a surrogate measure of skin barrier dysfunction, we sought to determine differences in transepidermal water loss (TEWL) among ichthyosis subtypes and correlate TEWL with clinical severity. Subjects with Netherton syndrome had the highest TEWL values (increased water loss), while TEWL values were lowest in subjects with epidermolytic ichthyosis. TEWL correlated with severity only in lamellar ichthyosis and age was inversely correlated with TEWL (r_s = −.213, P =.02). TEWL is an objective measure that complements disease severity in ichthyosis and may be used as an adjuvant to monitor treatment response.

Original language	English (US)
Pages (from-to)	771-773
Number of pages	3
Journal	Pediatric Dermatology
Volume	37
Issue number	4
DOIs	https://doi.org/10.1111/pde.14221
State	Published - Jul 1 2020
Externally published	Yes

Keywords

Ichthyosis
skin barrier

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Dermatology

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10.1111/pde.14221

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title = "Transepidermal water loss in the orphan forms of ichthyosis",

abstract = "As a surrogate measure of skin barrier dysfunction, we sought to determine differences in transepidermal water loss (TEWL) among ichthyosis subtypes and correlate TEWL with clinical severity. Subjects with Netherton syndrome had the highest TEWL values (increased water loss), while TEWL values were lowest in subjects with epidermolytic ichthyosis. TEWL correlated with severity only in lamellar ichthyosis and age was inversely correlated with TEWL (rs = −.213, P =.02). TEWL is an objective measure that complements disease severity in ichthyosis and may be used as an adjuvant to monitor treatment response.",

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AU - Erickson, Taylor R.

AU - Murphrey, Morgan B.

AU - Abu-Zayed, Hajar

AU - Wu, Benedict

AU - Ibler, Erin

AU - Rangel, Stephanie M.

AU - Paller, Amy S.

PY - 2020/7/1

Y1 - 2020/7/1

N2 - As a surrogate measure of skin barrier dysfunction, we sought to determine differences in transepidermal water loss (TEWL) among ichthyosis subtypes and correlate TEWL with clinical severity. Subjects with Netherton syndrome had the highest TEWL values (increased water loss), while TEWL values were lowest in subjects with epidermolytic ichthyosis. TEWL correlated with severity only in lamellar ichthyosis and age was inversely correlated with TEWL (rs = −.213, P =.02). TEWL is an objective measure that complements disease severity in ichthyosis and may be used as an adjuvant to monitor treatment response.

AB - As a surrogate measure of skin barrier dysfunction, we sought to determine differences in transepidermal water loss (TEWL) among ichthyosis subtypes and correlate TEWL with clinical severity. Subjects with Netherton syndrome had the highest TEWL values (increased water loss), while TEWL values were lowest in subjects with epidermolytic ichthyosis. TEWL correlated with severity only in lamellar ichthyosis and age was inversely correlated with TEWL (rs = −.213, P =.02). TEWL is an objective measure that complements disease severity in ichthyosis and may be used as an adjuvant to monitor treatment response.

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Transepidermal water loss in the orphan forms of ichthyosis

Abstract

Keywords

ASJC Scopus subject areas

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