@article{2b02ba7a26044e55810040c346c2eb44,
title = "Transcutaneous Electrical Nerve Stimulation as a Treatment for Neuropathic Cough: A Tolerability and Feasibility Study",
abstract = "Transcutaneous electrical nerve stimulation (TENS) is a form of electroanalgesia used for neuropathic pain disorders. Refractory chronic cough, or “neuropathic cough,” may be physiologically similar to other neuropathic pain conditions. This study explored the tolerability and feasibility of using TENS as a treatment for neuropathic cough. Laryngeal TENS was administered to five subjects with neuropathic cough. One electrode was placed over the lateral thyrohyoid membrane, and a second over the cricothyroid space. A frequency of 120 Hz was applied for 30 min. Participants rated symptoms pre-, during, and post-TENS treatment using a Likert scale. Laryngeal TENS was well tolerated by all subjects. Adverse effects included brief neck discomfort when increasing TENS intensity and an event of mild post-treatment hoarseness. The self-reported scores trended toward a reduction in symptom severity during and after treatment. Controlled trials using this method would elucidate the use of TENS for treatment of patients suffering from chronic cough.",
keywords = "Chronic cough, Laryngeal irritability, Neuropathic cough, TENS, Transcutaneous electrical nerve stimulation",
author = "Alexandra Michalowski and Adam Haines and Naum Shaparin and Karina Gritsenko and Kaye, {Alan D.} and Cornett, {Elyse M.} and Lerner, {Michael Z.}",
note = "Funding Information: We would like to thank all of the participants in this study for their contribution to the advancement of medical knowledge. The work was performed at Albert Einstein College of Medicine, Bronx, New York, USA. No funding or sponsorship was received for this study or publication of this article. All named authors meet the International Committee of Medical Journal Editors (ICMJE) criteria for authorship for this article, take responsibility for the integrity of the work as a whole, and have given their approval for this version to be published. AM, NS, MZL contributed to the concept and design of the study. AM, AH, and MZL implemented the study protocol. AM, AH, NS, KG, ADK, MZL, and EMC all contributed to interpretation of results and preparation of the written manuscript. All authors agreed to the final version of the written manuscript and agree to be accountable for all aspects of the work. The principal investigator ML had full access to all the data in the study and takes full responsibility for the integrity of the data and the accuracy of the data analysis. This manuscript is based on work that was also presented as a poster presentation at the American Laryngological Association{\textquoteright}s 2018 Annual Meeting at COSM in National Harbor, Maryland on April 20, 2018. Alexandra Michalowski, Adam Haines, Naum Shaparin, Karina Gritsenko, Alan David Kaye, Michael Z Lerner, and Elyse M. Cornett have no financial relationships or conflicts of interest to disclose. Alexandra Michalowski has since changed affiliations and is currently affiliated with New York Presbyterian Hospital, New York, New York. This study was completed in accordance with the Einstein Institutional Review Board approval (identification number 2017–7703). The study protocol was designed and implemented in accordance with the Helsinki Declaration of 1964 and all of its later amendments. Informed consent was obtained from all potential participants prior to their decision to participate in this research. This consent process included a section for participants to agree to the use of photography that does not include the participants face for use in possible publications that result from this study. All photos obtained and published from this study were obtained and published with consent from the participant. The datasets generated during and/or analyzed during the current study are available from the corresponding author on reasonable request. Publisher Copyright: {\textcopyright} 2021, The Author(s).",
year = "2021",
month = dec,
doi = "10.1007/s40120-021-00255-2",
language = "English (US)",
volume = "10",
pages = "1127--1133",
journal = "Neurology and Therapy",
issn = "2193-8253",
publisher = "Springer Healthcare",
number = "2",
}