Transcatheter Tricuspid Valve Intervention in Patients With Previous Left Valve Surgery

Guillem Muntané-Carol; Maurizio Taramasso; Mizuki Miura; Mara Gavazzoni; Alberto Pozzoli; Hannes Alessandrini; Azeem Latib; Adrian Attinger-Toller; Luigi Biasco; Daniel Braun; Eric Brochet; Kim A. Connelly; Horst Sievert; Paolo Denti; Edith Lubos; Sebastian Ludwig; Daniel Kalbacher; Rodrigo Estevez-Loureiro; Neil Fam; Christian Frerker; Edwin Ho; Jean Michel Juliard; Ryan Kaple; Susheel Kodali; Felix Kreidel; Claudia Harr; Alexander Lauten; Julia Lurz; Karl Patrik Kresoja; Vanessa Monivas; Michael Mehr; Tamim Nazif; Georg Nickening; Giovanni Pedrazzini; François Philippon; Fabien Praz; Rishi Puri; Ulrich Schäfer; Joachim Schofer; Gilbert H.L. Tang; Ahmed A. Khattab; Martin Andreas; Marco Russo; Holger Thiele; Matthias Unterhuber; Dominique Himbert; Marina Urena; Ralph Stephan von Bardeleben; John G. Webb; Marcel Weber; Mirjam Winkel; Michel Zuber; Jörg Hausleiter; Philipp Lurz; Francesco Maisano; Martin B. Leon; Rebecca T. Hahn; Josep Rodés-Cabau

doi:10.1016/j.cjca.2021.02.010

Transcatheter Tricuspid Valve Intervention in Patients With Previous Left Valve Surgery

Guillem Muntané-Carol, Maurizio Taramasso, Mizuki Miura, Mara Gavazzoni, Alberto Pozzoli, Hannes Alessandrini, Azeem Latib, Adrian Attinger-Toller, Luigi Biasco, Daniel Braun, Eric Brochet, Kim A. Connelly, Horst Sievert, Paolo Denti, Edith Lubos, Sebastian Ludwig, Daniel Kalbacher, Rodrigo Estevez-Loureiro, Neil Fam, Christian FrerkerEdwin Ho, Jean Michel Juliard, Ryan Kaple, Susheel Kodali, Felix Kreidel, Claudia Harr, Alexander Lauten, Julia Lurz, Karl Patrik Kresoja, Vanessa Monivas, Michael Mehr, Tamim Nazif, Georg Nickening, Giovanni Pedrazzini, François Philippon, Fabien Praz, Rishi Puri, Ulrich Schäfer, Joachim Schofer, Gilbert H.L. Tang, Ahmed A. Khattab, Martin Andreas, Marco Russo, Holger Thiele, Matthias Unterhuber, Dominique Himbert, Marina Urena, Ralph Stephan von Bardeleben, John G. Webb, Marcel Weber, Mirjam Winkel, Michel Zuber, Jörg Hausleiter, Philipp Lurz, Francesco Maisano, Martin B. Leon, Rebecca T. Hahn, Josep Rodés-Cabau

Medicine

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Background: Scarce data exist on patients with previous left valve surgery (PLVS) undergoing transcatheter tricuspid valve intervention (TTVI). This study sought to investigate the procedural and early outcomes in patients with PLVS undergoing TTVI. Methods: This was a subanalysis of the multicenter TriValve registry including 462 patients, 82 (18%) with PLVS. Data were analyzed according to the presence of PLVS in the overall cohort and in a propensity score–matched population including 51 and 115 patients with and without PLVS, respectively. Results: Patients with PLVS were younger (72 ± 10 vs 78 ± 9 years; p < 0.01) and more frequently female (67.1% vs 53.2%; P = 0.02). Similar rates of procedural success (PLVS 80.5%; no-PLVS 82.1%; P = 0.73), and 30-day mortality (PLVS 2.4%, no-PLVS 3.4%; P = 0.99) were observed. After matching, there were no significant differences in both all-cause rehospitalisation (PLVS 21.1%, no-PLVS 26.5%; P = 0.60) and all-cause mortality (PLVS 9.8%, no-PLVS 6.7%; P = 0.58). At last follow-up (median 6 [interquartile range 1-12] months after the procedure), most patients (81.8%) in the PLVS group were in NYHA functional class I-II (P = 0.12 vs no-PLVS group), and TR grade was ≤ 2 in 82.6% of patients (P = 0.096 vs no-PVLS group). A poorer right ventricular function and previous heart failure hospitalization determined increased risks of procedural failure and poorer outcomes at follow-up, respectively. Conclusions: In patients with PLVS, TTVI was associated with high rates of procedural success and low early mortality. However, about one-third of patients required rehospitalisation or died at midterm follow-up. These results would support TTVI as a reasonable alternative to redo surgery in patients with PLVS and suggest the importance of earlier treatment to improve clinical outcomes.

Original language	English (US)
Pages (from-to)	1094-1102
Number of pages	9
Journal	Canadian Journal of Cardiology
Volume	37
Issue number	7
DOIs	https://doi.org/10.1016/j.cjca.2021.02.010
State	Published - Jul 2021

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

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10.1016/j.cjca.2021.02.010

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Muntané-Carol, G., Taramasso, M., Miura, M., Gavazzoni, M., Pozzoli, A., Alessandrini, H., Latib, A., Attinger-Toller, A., Biasco, L., Braun, D., Brochet, E., Connelly, K. A., Sievert, H., Denti, P., Lubos, E., Ludwig, S., Kalbacher, D., Estevez-Loureiro, R., Fam, N., ... Rodés-Cabau, J. (2021). Transcatheter Tricuspid Valve Intervention in Patients With Previous Left Valve Surgery. Canadian Journal of Cardiology, 37(7), 1094-1102. https://doi.org/10.1016/j.cjca.2021.02.010

Muntané-Carol, G, Taramasso, M, Miura, M, Gavazzoni, M, Pozzoli, A, Alessandrini, H, Latib, A, Attinger-Toller, A, Biasco, L, Braun, D, Brochet, E, Connelly, KA, Sievert, H, Denti, P, Lubos, E, Ludwig, S, Kalbacher, D, Estevez-Loureiro, R, Fam, N, Frerker, C, Ho, E, Juliard, JM, Kaple, R, Kodali, S, Kreidel, F, Harr, C, Lauten, A, Lurz, J, Kresoja, KP, Monivas, V, Mehr, M, Nazif, T, Nickening, G, Pedrazzini, G, Philippon, F, Praz, F, Puri, R, Schäfer, U, Schofer, J, Tang, GHL, Khattab, AA, Andreas, M, Russo, M, Thiele, H, Unterhuber, M, Himbert, D, Urena, M, von Bardeleben, RS, Webb, JG, Weber, M, Winkel, M, Zuber, M, Hausleiter, J, Lurz, P, Maisano, F, Leon, MB, Hahn, RT & Rodés-Cabau, J 2021, 'Transcatheter Tricuspid Valve Intervention in Patients With Previous Left Valve Surgery', Canadian Journal of Cardiology, vol. 37, no. 7, pp. 1094-1102. https://doi.org/10.1016/j.cjca.2021.02.010

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title = "Transcatheter Tricuspid Valve Intervention in Patients With Previous Left Valve Surgery",

abstract = "Background: Scarce data exist on patients with previous left valve surgery (PLVS) undergoing transcatheter tricuspid valve intervention (TTVI). This study sought to investigate the procedural and early outcomes in patients with PLVS undergoing TTVI. Methods: This was a subanalysis of the multicenter TriValve registry including 462 patients, 82 (18%) with PLVS. Data were analyzed according to the presence of PLVS in the overall cohort and in a propensity score–matched population including 51 and 115 patients with and without PLVS, respectively. Results: Patients with PLVS were younger (72 ± 10 vs 78 ± 9 years; p < 0.01) and more frequently female (67.1% vs 53.2%; P = 0.02). Similar rates of procedural success (PLVS 80.5%; no-PLVS 82.1%; P = 0.73), and 30-day mortality (PLVS 2.4%, no-PLVS 3.4%; P = 0.99) were observed. After matching, there were no significant differences in both all-cause rehospitalisation (PLVS 21.1%, no-PLVS 26.5%; P = 0.60) and all-cause mortality (PLVS 9.8%, no-PLVS 6.7%; P = 0.58). At last follow-up (median 6 [interquartile range 1-12] months after the procedure), most patients (81.8%) in the PLVS group were in NYHA functional class I-II (P = 0.12 vs no-PLVS group), and TR grade was ≤ 2 in 82.6% of patients (P = 0.096 vs no-PVLS group). A poorer right ventricular function and previous heart failure hospitalization determined increased risks of procedural failure and poorer outcomes at follow-up, respectively. Conclusions: In patients with PLVS, TTVI was associated with high rates of procedural success and low early mortality. However, about one-third of patients required rehospitalisation or died at midterm follow-up. These results would support TTVI as a reasonable alternative to redo surgery in patients with PLVS and suggest the importance of earlier treatment to improve clinical outcomes.",

author = "Guillem Muntan{\'e}-Carol and Maurizio Taramasso and Mizuki Miura and Mara Gavazzoni and Alberto Pozzoli and Hannes Alessandrini and Azeem Latib and Adrian Attinger-Toller and Luigi Biasco and Daniel Braun and Eric Brochet and Connelly, {Kim A.} and Horst Sievert and Paolo Denti and Edith Lubos and Sebastian Ludwig and Daniel Kalbacher and Rodrigo Estevez-Loureiro and Neil Fam and Christian Frerker and Edwin Ho and Juliard, {Jean Michel} and Ryan Kaple and Susheel Kodali and Felix Kreidel and Claudia Harr and Alexander Lauten and Julia Lurz and Kresoja, {Karl Patrik} and Vanessa Monivas and Michael Mehr and Tamim Nazif and Georg Nickening and Giovanni Pedrazzini and Fran{\c c}ois Philippon and Fabien Praz and Rishi Puri and Ulrich Sch{\"a}fer and Joachim Schofer and Tang, {Gilbert H.L.} and Khattab, {Ahmed A.} and Martin Andreas and Marco Russo and Holger Thiele and Matthias Unterhuber and Dominique Himbert and Marina Urena and {von Bardeleben}, {Ralph Stephan} and Webb, {John G.} and Marcel Weber and Mirjam Winkel and Michel Zuber and J{\"o}rg Hausleiter and Philipp Lurz and Francesco Maisano and Leon, {Martin B.} and Hahn, {Rebecca T.} and Josep Rod{\'e}s-Cabau",

note = "Publisher Copyright: {\textcopyright} 2021 Canadian Cardiovascular Society",

year = "2021",

month = jul,

doi = "10.1016/j.cjca.2021.02.010",

language = "English (US)",

volume = "37",

pages = "1094--1102",

journal = "Canadian Journal of Cardiology",

issn = "0828-282X",

publisher = "Pulsus Group Inc.",

number = "7",

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TY - JOUR

T1 - Transcatheter Tricuspid Valve Intervention in Patients With Previous Left Valve Surgery

AU - Muntané-Carol, Guillem

AU - Taramasso, Maurizio

AU - Miura, Mizuki

AU - Gavazzoni, Mara

AU - Pozzoli, Alberto

AU - Alessandrini, Hannes

AU - Latib, Azeem

AU - Attinger-Toller, Adrian

AU - Biasco, Luigi

AU - Braun, Daniel

AU - Brochet, Eric

AU - Connelly, Kim A.

AU - Sievert, Horst

AU - Denti, Paolo

AU - Lubos, Edith

AU - Ludwig, Sebastian

AU - Kalbacher, Daniel

AU - Estevez-Loureiro, Rodrigo

AU - Fam, Neil

AU - Frerker, Christian

AU - Ho, Edwin

AU - Juliard, Jean Michel

AU - Kaple, Ryan

AU - Kodali, Susheel

AU - Kreidel, Felix

AU - Harr, Claudia

AU - Lauten, Alexander

AU - Lurz, Julia

AU - Kresoja, Karl Patrik

AU - Monivas, Vanessa

AU - Mehr, Michael

AU - Nazif, Tamim

AU - Nickening, Georg

AU - Pedrazzini, Giovanni

AU - Philippon, François

AU - Praz, Fabien

AU - Puri, Rishi

AU - Schäfer, Ulrich

AU - Schofer, Joachim

AU - Tang, Gilbert H.L.

AU - Khattab, Ahmed A.

AU - Andreas, Martin

AU - Russo, Marco

AU - Thiele, Holger

AU - Unterhuber, Matthias

AU - Himbert, Dominique

AU - Urena, Marina

AU - von Bardeleben, Ralph Stephan

AU - Webb, John G.

AU - Weber, Marcel

AU - Winkel, Mirjam

AU - Zuber, Michel

AU - Hausleiter, Jörg

AU - Lurz, Philipp

AU - Maisano, Francesco

AU - Leon, Martin B.

AU - Hahn, Rebecca T.

AU - Rodés-Cabau, Josep

PY - 2021/7

Y1 - 2021/7

N2 - Background: Scarce data exist on patients with previous left valve surgery (PLVS) undergoing transcatheter tricuspid valve intervention (TTVI). This study sought to investigate the procedural and early outcomes in patients with PLVS undergoing TTVI. Methods: This was a subanalysis of the multicenter TriValve registry including 462 patients, 82 (18%) with PLVS. Data were analyzed according to the presence of PLVS in the overall cohort and in a propensity score–matched population including 51 and 115 patients with and without PLVS, respectively. Results: Patients with PLVS were younger (72 ± 10 vs 78 ± 9 years; p < 0.01) and more frequently female (67.1% vs 53.2%; P = 0.02). Similar rates of procedural success (PLVS 80.5%; no-PLVS 82.1%; P = 0.73), and 30-day mortality (PLVS 2.4%, no-PLVS 3.4%; P = 0.99) were observed. After matching, there were no significant differences in both all-cause rehospitalisation (PLVS 21.1%, no-PLVS 26.5%; P = 0.60) and all-cause mortality (PLVS 9.8%, no-PLVS 6.7%; P = 0.58). At last follow-up (median 6 [interquartile range 1-12] months after the procedure), most patients (81.8%) in the PLVS group were in NYHA functional class I-II (P = 0.12 vs no-PLVS group), and TR grade was ≤ 2 in 82.6% of patients (P = 0.096 vs no-PVLS group). A poorer right ventricular function and previous heart failure hospitalization determined increased risks of procedural failure and poorer outcomes at follow-up, respectively. Conclusions: In patients with PLVS, TTVI was associated with high rates of procedural success and low early mortality. However, about one-third of patients required rehospitalisation or died at midterm follow-up. These results would support TTVI as a reasonable alternative to redo surgery in patients with PLVS and suggest the importance of earlier treatment to improve clinical outcomes.

AB - Background: Scarce data exist on patients with previous left valve surgery (PLVS) undergoing transcatheter tricuspid valve intervention (TTVI). This study sought to investigate the procedural and early outcomes in patients with PLVS undergoing TTVI. Methods: This was a subanalysis of the multicenter TriValve registry including 462 patients, 82 (18%) with PLVS. Data were analyzed according to the presence of PLVS in the overall cohort and in a propensity score–matched population including 51 and 115 patients with and without PLVS, respectively. Results: Patients with PLVS were younger (72 ± 10 vs 78 ± 9 years; p < 0.01) and more frequently female (67.1% vs 53.2%; P = 0.02). Similar rates of procedural success (PLVS 80.5%; no-PLVS 82.1%; P = 0.73), and 30-day mortality (PLVS 2.4%, no-PLVS 3.4%; P = 0.99) were observed. After matching, there were no significant differences in both all-cause rehospitalisation (PLVS 21.1%, no-PLVS 26.5%; P = 0.60) and all-cause mortality (PLVS 9.8%, no-PLVS 6.7%; P = 0.58). At last follow-up (median 6 [interquartile range 1-12] months after the procedure), most patients (81.8%) in the PLVS group were in NYHA functional class I-II (P = 0.12 vs no-PLVS group), and TR grade was ≤ 2 in 82.6% of patients (P = 0.096 vs no-PVLS group). A poorer right ventricular function and previous heart failure hospitalization determined increased risks of procedural failure and poorer outcomes at follow-up, respectively. Conclusions: In patients with PLVS, TTVI was associated with high rates of procedural success and low early mortality. However, about one-third of patients required rehospitalisation or died at midterm follow-up. These results would support TTVI as a reasonable alternative to redo surgery in patients with PLVS and suggest the importance of earlier treatment to improve clinical outcomes.

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DO - 10.1016/j.cjca.2021.02.010

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AN - SCOPUS:85108283303

SN - 0828-282X

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SP - 1094

EP - 1102

JO - Canadian Journal of Cardiology

JF - Canadian Journal of Cardiology

IS - 7

ER -

Transcatheter Tricuspid Valve Intervention in Patients With Previous Left Valve Surgery

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