TY - JOUR
T1 - Transcatheter Closure of Patent Foramen Ovale
T2 - Randomized Trial Update
AU - Arfaras-Melainis, Angelos
AU - Palaiodimos, Leonidas
AU - Mojadidi, Mohammad K.
N1 - Publisher Copyright:
© 2019 Elsevier Inc.
PY - 2019/10
Y1 - 2019/10
N2 - A patent foramen ovale (PFO) is found in about one-quarter of all adults, but the prevalence increases to approximately half of those with a history of a so-called cryptogenic stroke. The true efficacy of PFO closure for prevention of recurrent paradoxical embolism has been debated for years, as the early 3 randomized trials did not show a statistically significant benefit of PFO closure over standard-of-care medical therapy. However, 3 recent randomized trials along with the long-term follow-up data from the largest early trial demonstrated superiority of device closure for secondary stroke prevention.
AB - A patent foramen ovale (PFO) is found in about one-quarter of all adults, but the prevalence increases to approximately half of those with a history of a so-called cryptogenic stroke. The true efficacy of PFO closure for prevention of recurrent paradoxical embolism has been debated for years, as the early 3 randomized trials did not show a statistically significant benefit of PFO closure over standard-of-care medical therapy. However, 3 recent randomized trials along with the long-term follow-up data from the largest early trial demonstrated superiority of device closure for secondary stroke prevention.
KW - Cryptogenic stroke
KW - ESUS
KW - Embolic stroke of undetermined source
KW - PFO
KW - PFO closure
KW - Stroke prevention
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U2 - 10.1016/j.iccl.2019.05.002
DO - 10.1016/j.iccl.2019.05.002
M3 - Review article
C2 - 31445719
AN - SCOPUS:85069656710
SN - 2211-7458
VL - 8
SP - 341
EP - 356
JO - Interventional Cardiology Clinics
JF - Interventional Cardiology Clinics
IS - 4
ER -