Transcatheter aortic valve implantation in patients with bicuspid valve morphology: a roadmap towards standardization

Tian Yuan Xiong, Walid Ben Ali, Yuan Feng, Kentaro Hayashida, Hasan Jilaihawi, Azeem Latib, Michael Kang Yin Lee, Martin B. Leon, Raj R. Makkar, Thomas Modine, Christoph Naber, Yong Peng, Nicolo Piazza, Michael J. Reardon, Simon Redwood, Ashok Seth, Lars Sondergaard, Edgar Tay, Didier Tchetche, Wei Hsian YinMao Chen, Bernard Prendergast, Darren Mylotte

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


Indications for transcatheter aortic valve implantation (TAVI) have expanded in many countries to include patients with aortic stenosis who are at low surgical risk, and a similar expansion to this cohort is anticipated elsewhere in the world, together with an increase in the proportion of patients with bicuspid aortic valve (BAV) morphology as the age of the patients being treated decreases. To date, patients with BAV have been excluded from major randomized trials of TAVI owing to anatomical considerations. As a consequence, BAV has been a relative contraindication to the use of TAVI in international guidelines. Although clinical experience and observational data are accumulating, BAV presents numerous anatomical challenges for successful TAVI, despite advances in device design. Furthermore, in those with BAV, substantial geographical variation exists in patient characteristics, clinical approach and procedural strategy. Therefore, in this Roadmap article, we summarize the existing evidence and provide consensus recommendations from an international group of experts on the application of TAVI in patients with BAV in advance of the anticipated growth in the use of this procedure in this challenging cohort of patients.

Original languageEnglish (US)
Pages (from-to)52-67
Number of pages16
JournalNature Reviews Cardiology
Issue number1
StatePublished - Jan 2023
Externally publishedYes

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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