Trans-subclavian versus transapical access for transcatheter aortic valve implantation: A multicenter study

Cristina Ciuca, Giuseppe Tarantini, Azeem Latib, Valeria Gasparetto, Carlo Savini, Marco Di Eusanio, Massimo Napodano, Francesco Maisano, Gino Gerosa, Alessandro Sticchi, Antonio Marzocchi, Ottavio Alfieri, Antonio Colombo, Francesco Saia

Research output: Contribution to journalArticlepeer-review

46 Scopus citations


Objectives To compare the outcomes of trans-subclavian (TS) and transapical (TA) access for transcatheter aortic valve implantation (TAVI). Background A considerable proportion of patients undergoing TAVI are not eligible for transfemoral approach. To date, there are few data to guide the choice between alternative vascular access routes. Methods Among 874 consecutive patients who underwent TAVI, 202 procedures were performed through TA (n = 142, 70.3%) or TS (n = 60, 29.7%) access. Medtronic Corevalve (CV, Medtronic, Minneapolis, MN) was implanted in 17.3% of the patients, the Edwards-Sapien (ES, Edwards Lifesciences Inc., Irvine, CA) in 81.2% and other prostheses in 0.1%. In-hospital and long-term outcome were assessed using the Valve Academic Research Consortium (VARC)-2 definitions. Results Mean age was 82 ± 6 years, STS score 9.3 ± 7.9%. The 2 groups showed a relevant imbalance in baseline characteristics. In hospital mortality was 6.4% (1.7% TS vs. 8.4% TA, P = 0.06), stroke 2.0%, acute myocardial infarction 1.0%, acute kidney injury 39.4%, sepsis 4.0% with no significant differences between groups, while bleeding was more frequent in TA patients (53.5% vs. 11.7% TS, P < 0.001). One- and 2-year survival was 85.2% and 73.2% in TS patients, and 83.9% and 74.9% in TA patients (P = ns for both). Access site was not an independent predictor of mortality at multivariable analysis. Conclusion Transapical compared with trans-subclavian access for TAVI was associated with a nonsignificant trend to increased periprocedural events. However, 1- and 2-year survival appears similar.

Original languageEnglish (US)
Pages (from-to)332-338
Number of pages7
JournalCatheterization and Cardiovascular Interventions
Issue number2
StatePublished - Feb 1 2016
Externally publishedYes


  • aortic stenosis
  • outcome
  • transcatheter aortic valve replacement
  • vascular access

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine


Dive into the research topics of 'Trans-subclavian versus transapical access for transcatheter aortic valve implantation: A multicenter study'. Together they form a unique fingerprint.

Cite this