Toward new paradigms of seizure detection

Devin K. Binder, Sheryl R. Haut

Research output: Contribution to journalReview articlepeer-review

25 Scopus citations


Great effort has been made toward defining and characterizing the pre-ictal state. Many studies have pursued the idea that there are recognizable electrographic (EEG-based) features which occur before overt clinical seizure activity. However, development of reliable EEG-based seizure detection and prediction algorithms has been difficult. In this review, we discuss the concepts of seizure detection vs. prediction and the pre-ictal "clinical milieu" and "EEG milieu". We proceed to discuss novel concepts of seizure detection based on the pre-ictal "physiological milieu"; in particular, we indicate some early evidence for the hypothesis that pre-ictal cell swelling/extracellular space constriction can be detected with novel optical methods. Development and validation of optical seizure detection technology could provide an entirely new translational approach for the many patients with intractable epilepsy.This article is part of a Special Issue entitled "The Future of Translational Epilepsy Research".

Original languageEnglish (US)
Pages (from-to)247-252
Number of pages6
JournalEpilepsy and Behavior
Issue number3
StatePublished - Mar 2013


  • Detection
  • Electroencephalography
  • Hippocampus
  • Optical coherence tomography
  • Optics
  • Pre-seizure state
  • Prediction
  • Seizure

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Behavioral Neuroscience


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