TY - JOUR
T1 - Toward new classification criteria for juvenile idiopathic arthritis
T2 - First steps, pediatric rheumatology international trials organization international consensus
AU - for the Pediatric Rheumatology International Trials Organization (PRINTO)
AU - Martini, Alberto
AU - Ravelli, Angelo
AU - Avcin, Tadej
AU - Beresford, Michael W.
AU - Burgos-Vargas, Ruben
AU - Cuttica, Ruben
AU - Ilowite, Norman T.
AU - Khubchandani, Raju
AU - Laxer, Ronald M.
AU - Lovell, Daniel J.
AU - Petty, Ross E.
AU - Wallace, Carol A.
AU - Wulffraat, Nico M.
AU - Pistorio, Angela
AU - Ruperto, Nicolino
N1 - Publisher Copyright:
© 2019 The Journal of Rheumatology.
PY - 2019/2/1
Y1 - 2019/2/1
N2 - Objective. To revise the current juvenile idiopathic arthritis (JIA) International League of Associations for Rheumatology (ILAR) classification criteria with an evidence-based approach, using clinical and routine laboratory measures available worldwide, to identify homogeneous clinical groups and to distinguish those forms of chronic arthritis typically seen only in children from the childhood counterpart of adult diseases. Methods. The overall project consists of 4 steps. This work represents Step 1, a Delphi Web-based consensus and Step 2, an international nominal group technique (NGT) consensus conference for the new provisional Pediatric Rheumatology International Trials Organization JIA classification criteria. A future large data collection of at least 1000 new-onset JIA patients (Step 3) followed by analysis and NGT consensus (Step 4) will provide data for the evidence-based validation of the JIA classification criteria. Results. In Step 1, three Delphi rounds of interactions were implemented to revise the 7 ILAR JIA categories. In Step 2, forty-seven questions with electronic voting were implemented to derive the new proposed criteria. Four disorders were proposed: (a) systemic JIA; (b) rheumatoid factor-positive JIA; (c) enthesitis/spondylitis-related JIA; and (d) early-onset antinuclear antibody-positive JIA. The other forms were gathered under the term "others." These will be analyzed during the prospective data collection using a list of descriptors to see whether the clustering of some of them could identify homogeneous entities. Conclusion. An international consensus was reached to identify different proposed homogeneous chronic disorders that fall under the historical term JIA. These preliminary criteria will be formally validated with a dedicated project.
AB - Objective. To revise the current juvenile idiopathic arthritis (JIA) International League of Associations for Rheumatology (ILAR) classification criteria with an evidence-based approach, using clinical and routine laboratory measures available worldwide, to identify homogeneous clinical groups and to distinguish those forms of chronic arthritis typically seen only in children from the childhood counterpart of adult diseases. Methods. The overall project consists of 4 steps. This work represents Step 1, a Delphi Web-based consensus and Step 2, an international nominal group technique (NGT) consensus conference for the new provisional Pediatric Rheumatology International Trials Organization JIA classification criteria. A future large data collection of at least 1000 new-onset JIA patients (Step 3) followed by analysis and NGT consensus (Step 4) will provide data for the evidence-based validation of the JIA classification criteria. Results. In Step 1, three Delphi rounds of interactions were implemented to revise the 7 ILAR JIA categories. In Step 2, forty-seven questions with electronic voting were implemented to derive the new proposed criteria. Four disorders were proposed: (a) systemic JIA; (b) rheumatoid factor-positive JIA; (c) enthesitis/spondylitis-related JIA; and (d) early-onset antinuclear antibody-positive JIA. The other forms were gathered under the term "others." These will be analyzed during the prospective data collection using a list of descriptors to see whether the clustering of some of them could identify homogeneous entities. Conclusion. An international consensus was reached to identify different proposed homogeneous chronic disorders that fall under the historical term JIA. These preliminary criteria will be formally validated with a dedicated project.
KW - Juvenile idiopathic arthritis
KW - antinuclear antibodies
KW - autoimmune diseases
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U2 - 10.3899/jrheum.180168
DO - 10.3899/jrheum.180168
M3 - Article
C2 - 30275259
AN - SCOPUS:85060916928
SN - 0315-162X
VL - 46
SP - 190
EP - 197
JO - Journal of Rheumatology
JF - Journal of Rheumatology
IS - 2
ER -