TY - JOUR
T1 - Total plasma homocysteine values among elderly subjects
T2 - Findings from the Maracaibo Aging Study
AU - Molero, Aldrin E.
AU - Altimari, Carmen C.
AU - Duran, Dariana A.
AU - Garcia, Esperanza
AU - Pino-Ramirez, Gloria
AU - Maestre, Gladys E.
N1 - Funding Information:
This study was supported by grants from FONACIT G-97000726 and 98002041 and Funda Conciencia.
PY - 2006/10
Y1 - 2006/10
N2 - Objectives: The present study generated baseline data for total homocysteine (tHcy) in elderly Caribbeans of Hispanic ancestry, residing in Venezuela, their country of origin. Design and methods: 2106 participants in the Maracaibo Aging Study (MAS), older than 55 years, underwent standardized clinical and laboratory assessments, including measurement of plasma tHcy levels, folate, and vitamin B12 in fasting samples. Results: tHcy concentration in the healthy, normative group ranged from 4.1 to 31.8 μmol/L, with a median of 11.5 ± 4.7 μmol/L. tHcy level increased with age, was significantly higher in men than in women, and exhibited inverse correlations with folate and vitamin B12. Conclusions: tHcy levels of the MAS participants were generally higher than levels previously reported for community-dwelling elderly populations from other countries. The normative centile curves for tHcy can be used in disease risk analysis for this population, and possibly for other Hispanic populations residing in the Caribbean.
AB - Objectives: The present study generated baseline data for total homocysteine (tHcy) in elderly Caribbeans of Hispanic ancestry, residing in Venezuela, their country of origin. Design and methods: 2106 participants in the Maracaibo Aging Study (MAS), older than 55 years, underwent standardized clinical and laboratory assessments, including measurement of plasma tHcy levels, folate, and vitamin B12 in fasting samples. Results: tHcy concentration in the healthy, normative group ranged from 4.1 to 31.8 μmol/L, with a median of 11.5 ± 4.7 μmol/L. tHcy level increased with age, was significantly higher in men than in women, and exhibited inverse correlations with folate and vitamin B12. Conclusions: tHcy levels of the MAS participants were generally higher than levels previously reported for community-dwelling elderly populations from other countries. The normative centile curves for tHcy can be used in disease risk analysis for this population, and possibly for other Hispanic populations residing in the Caribbean.
KW - Aging
KW - Caribbean
KW - Elderly
KW - Homocysteine
KW - Risk factor
UR - http://www.scopus.com/inward/record.url?scp=33748985830&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33748985830&partnerID=8YFLogxK
U2 - 10.1016/j.clinbiochem.2006.07.005
DO - 10.1016/j.clinbiochem.2006.07.005
M3 - Article
C2 - 16959233
AN - SCOPUS:33748985830
SN - 0009-9120
VL - 39
SP - 1007
EP - 1015
JO - Clinical Biochemistry
JF - Clinical Biochemistry
IS - 10
ER -