TY - JOUR
T1 - Total energy expenditure as assessed by doubly labeled water and all-cause mortality in a cohort of postmenopausal women
AU - Prentice, Ross L.
AU - Aragaki, Aaron K.
AU - Manson, Jo Ann E.
AU - Schoeller, Dale A.
AU - Tinker, Lesley F.
AU - Mossavar-Rahmani, Yasmin
AU - Wallace, Robert B.
AU - LaMonte, Michael J.
AU - Tooze, Janet A.
AU - Johnson, Karen C.
AU - Lampe, Johanna W.
AU - Neuhouser, Marian L.
N1 - Funding Information:
This work was supported by the National Heart, Lung, and Blood Institute , National Institutes of Health , United States Department of Health and Human Services (contracts HHSN268202100046C , HHSN268202100001C , HHSN268202100002C , HHSN268202100003C , HHSN268202100004C , and HHSN271202100004C ); and National Cancer Institute , National Institutes of Health, United States Department of Health and Human Services grant R01 CA119171 .
Publisher Copyright:
© 2023 American Society for Nutrition
PY - 2023/5
Y1 - 2023/5
N2 - Background: The association of TEE with all-cause mortality is uncertain, as is the dependence of this association on age. Objectives: To examine the association between TEE and all-cause mortality, and its age interaction, in a Women's Health Initiative (WHI) cohort of postmenopausal United States women (1992–present). Methods: A cohort of 1131 WHI participants having DLW TEE assessment of ∼10.0 y (median) following WHI enrollment with ∼13.7 y (median) of subsequent follow-up, was used to study the EE associations with all-cause mortality. To enhance the comparability of TEE and total EI, key analyses excluded participants having >5% weight change between WHI enrollment and DLW assessment. The influence of participant age on mortality associations was examined, as was the ability of concurrent and earlier weight and height measurements to explain the results. Results: There were 308 deaths following the TEE assessment through 2021. TEE was unrelated to overall mortality (P = 0.83) in this cohort of generally healthy, older (mean 71 y at TEE assessment) United States women. However, this potential association varied with age (P = 0.003). Higher TEE was associated with a higher mortality rate at the age of 60 y and a lower mortality rate at the age of 80 y. Within the weight-stable subset (532 participants, 129 deaths), TEE was weakly positively related to overall mortality (P = 0.08). This association also varied with age (P = 0.03), with mortality HRs (95% CIs) for a 20% increment in TEE of 2.33 (1.24, 4.36) at the age of 60 y, 1.49 (1.10, 2.02) at 70 y of age, and 0.96 (0.66, 1.38) at 80 y of age. This pattern remained, although was somewhat attenuated, following control for baseline weight and weight changes between WHI enrollment and TEE assessment. Conclusions: Higher EE is associated with higher all-cause mortality among younger postmenopausal women, only partially explained by weight and weight change. This study is registered with clinicaltrials.gov identifier: NCT00000611.
AB - Background: The association of TEE with all-cause mortality is uncertain, as is the dependence of this association on age. Objectives: To examine the association between TEE and all-cause mortality, and its age interaction, in a Women's Health Initiative (WHI) cohort of postmenopausal United States women (1992–present). Methods: A cohort of 1131 WHI participants having DLW TEE assessment of ∼10.0 y (median) following WHI enrollment with ∼13.7 y (median) of subsequent follow-up, was used to study the EE associations with all-cause mortality. To enhance the comparability of TEE and total EI, key analyses excluded participants having >5% weight change between WHI enrollment and DLW assessment. The influence of participant age on mortality associations was examined, as was the ability of concurrent and earlier weight and height measurements to explain the results. Results: There were 308 deaths following the TEE assessment through 2021. TEE was unrelated to overall mortality (P = 0.83) in this cohort of generally healthy, older (mean 71 y at TEE assessment) United States women. However, this potential association varied with age (P = 0.003). Higher TEE was associated with a higher mortality rate at the age of 60 y and a lower mortality rate at the age of 80 y. Within the weight-stable subset (532 participants, 129 deaths), TEE was weakly positively related to overall mortality (P = 0.08). This association also varied with age (P = 0.03), with mortality HRs (95% CIs) for a 20% increment in TEE of 2.33 (1.24, 4.36) at the age of 60 y, 1.49 (1.10, 2.02) at 70 y of age, and 0.96 (0.66, 1.38) at 80 y of age. This pattern remained, although was somewhat attenuated, following control for baseline weight and weight changes between WHI enrollment and TEE assessment. Conclusions: Higher EE is associated with higher all-cause mortality among younger postmenopausal women, only partially explained by weight and weight change. This study is registered with clinicaltrials.gov identifier: NCT00000611.
KW - all-cause mortality
KW - body weight
KW - doubly labeled water
KW - energy expenditure
KW - energy intake
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U2 - 10.1016/j.ajcnut.2023.02.023
DO - 10.1016/j.ajcnut.2023.02.023
M3 - Article
C2 - 36889672
AN - SCOPUS:85150755680
SN - 0002-9165
VL - 117
SP - 955
EP - 963
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
IS - 5
ER -