Tolerization of dendritic cells by Ts cells: The crucial role of inhibitory receptors ILT3 and ILT4

C. C. Chang; R. Ciubotariu; J. S. Manavalan; J. Yuan; A. I. Colovai; F. Piazza; S. Lederman; M. Colonna; R. Cortesini; R. Dalla-Favera; N. Suciu-Foca

doi:10.1038/ni760

Tolerization of dendritic cells by T_s cells: The crucial role of inhibitory receptors ILT3 and ILT4

C. C. Chang, R. Ciubotariu, J. S. Manavalan, J. Yuan, A. I. Colovai, F. Piazza, S. Lederman, M. Colonna, R. Cortesini, R. Dalla-Favera, N. Suciu-Foca

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720 Scopus citations

Abstract

Immunoglobulin-like transcript 3 (ILT3) and ILT4 belong to a family of inhibitory receptors expressed by human monocytes and dendritic cells. We show here that CD8⁺CD28⁻ alloantigen-specific T suppressor (T_s) cells induce the up-regulation of ILT3 and ILT4 on monocytes and dendritic cells, rendering these antigen-presenting cells (APCs) tolerogenic. Tolerogenic APCs show reduced expression of costimulatory molecules and induce antigen-specific unresponsiveness in CD4⁺T helper cells. Studies of human heart transplant recipients showed that rejection-free patients have circulating T_s cells, which induce the up-regulation of ILT3 and ILT4 in donor APCs. These findings demonstrate an important mechanism of immune regulation.

Original language	English (US)
Pages (from-to)	237-243
Number of pages	7
Journal	Nature Immunology
Volume	3
Issue number	3
DOIs	https://doi.org/10.1038/ni760
State	Published - Mar 2002
Externally published	Yes

ASJC Scopus subject areas

Immunology and Allergy
Immunology

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title = "Tolerization of dendritic cells by Ts cells: The crucial role of inhibitory receptors ILT3 and ILT4",

abstract = "Immunoglobulin-like transcript 3 (ILT3) and ILT4 belong to a family of inhibitory receptors expressed by human monocytes and dendritic cells. We show here that CD8+CD28− alloantigen-specific T suppressor (Ts) cells induce the up-regulation of ILT3 and ILT4 on monocytes and dendritic cells, rendering these antigen-presenting cells (APCs) tolerogenic. Tolerogenic APCs show reduced expression of costimulatory molecules and induce antigen-specific unresponsiveness in CD4+T helper cells. Studies of human heart transplant recipients showed that rejection-free patients have circulating Ts cells, which induce the up-regulation of ILT3 and ILT4 in donor APCs. These findings demonstrate an important mechanism of immune regulation.",

author = "Chang, {C. C.} and R. Ciubotariu and Manavalan, {J. S.} and J. Yuan and Colovai, {A. I.} and F. Piazza and S. Lederman and M. Colonna and R. Cortesini and R. Dalla-Favera and N. Suciu-Foca",

note = "Funding Information: Acknowledgments We thank Z. Liu, J. Fan, G.Vlad, M. Mirza and E. Ho for their help. Supported by grants from the NIH and the Interuniversitary Organ Transplantation Consortium, Rome, Italy.",

year = "2002",

month = mar,

doi = "10.1038/ni760",

language = "English (US)",

volume = "3",

pages = "237--243",

journal = "Nature Immunology",

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T2 - The crucial role of inhibitory receptors ILT3 and ILT4

AU - Chang, C. C.

AU - Ciubotariu, R.

AU - Manavalan, J. S.

AU - Yuan, J.

AU - Colovai, A. I.

AU - Piazza, F.

AU - Lederman, S.

AU - Colonna, M.

AU - Cortesini, R.

AU - Dalla-Favera, R.

AU - Suciu-Foca, N.

N1 - Funding Information: Acknowledgments We thank Z. Liu, J. Fan, G.Vlad, M. Mirza and E. Ho for their help. Supported by grants from the NIH and the Interuniversitary Organ Transplantation Consortium, Rome, Italy.

PY - 2002/3

Y1 - 2002/3

N2 - Immunoglobulin-like transcript 3 (ILT3) and ILT4 belong to a family of inhibitory receptors expressed by human monocytes and dendritic cells. We show here that CD8+CD28− alloantigen-specific T suppressor (Ts) cells induce the up-regulation of ILT3 and ILT4 on monocytes and dendritic cells, rendering these antigen-presenting cells (APCs) tolerogenic. Tolerogenic APCs show reduced expression of costimulatory molecules and induce antigen-specific unresponsiveness in CD4+T helper cells. Studies of human heart transplant recipients showed that rejection-free patients have circulating Ts cells, which induce the up-regulation of ILT3 and ILT4 in donor APCs. These findings demonstrate an important mechanism of immune regulation.

AB - Immunoglobulin-like transcript 3 (ILT3) and ILT4 belong to a family of inhibitory receptors expressed by human monocytes and dendritic cells. We show here that CD8+CD28− alloantigen-specific T suppressor (Ts) cells induce the up-regulation of ILT3 and ILT4 on monocytes and dendritic cells, rendering these antigen-presenting cells (APCs) tolerogenic. Tolerogenic APCs show reduced expression of costimulatory molecules and induce antigen-specific unresponsiveness in CD4+T helper cells. Studies of human heart transplant recipients showed that rejection-free patients have circulating Ts cells, which induce the up-regulation of ILT3 and ILT4 in donor APCs. These findings demonstrate an important mechanism of immune regulation.

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JO - Nature Immunology

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Tolerization of dendritic cells by T_s cells: The crucial role of inhibitory receptors ILT3 and ILT4

Abstract

ASJC Scopus subject areas

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