Tn and STn are members of a family of carbohydrate tumor antigens that possess carbohydrate-carbohydrate interactions

Marit Sletmoen; Thomas A. Gerken; Bjørn T. Stokke; Joy Burchell; C. Fred Brewer

doi:10.1093/glycob/cwy032

Tn and STn are members of a family of carbohydrate tumor antigens that possess carbohydrate-carbohydrate interactions

Marit Sletmoen, Thomas A. Gerken, Bjørn T. Stokke, Joy Burchell, C. Fred Brewer

Molecular Pharmacology

Research output: Contribution to journal › Review article › peer-review

11 Scopus citations

Abstract

The mucin-type O-glycome in cancer aberrantly expresses the truncated glycans Tn (GalNAcα1-Ser/ Thr) and STn (Neu5Acα2,6GalNAcα1-Ser/Thr). However, the role of Tn and STn in cancer and other diseases is not well understood. Our recent discovery of the self-binding properties (carbohydrate- carbohydrate interactions, CCIs) of Tn (Tn-Tn) and STn (STn-STn) provides a model for their possible roles in cellular transformation. We also review evidence that Tn and STn are members of a larger family of glycan tumor antigens that possess CCIs, whichmay participate in oncogenesis.

Original language	English (US)
Pages (from-to)	437-442
Number of pages	6
Journal	Glycobiology
Volume	28
Issue number	7
DOIs	https://doi.org/10.1093/glycob/cwy032
State	Published - Jul 1 2018

Keywords

Neu5Gc-GM3
Tn and STn cancer antigens
carbohydrate tumor antigens
carbohydrate-carbohydrate interactions
mechanism of action
optical tweezers

ASJC Scopus subject areas

Biochemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1093/glycob/cwy032

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title = "Tn and STn are members of a family of carbohydrate tumor antigens that possess carbohydrate-carbohydrate interactions",

abstract = "The mucin-type O-glycome in cancer aberrantly expresses the truncated glycans Tn (GalNAcα1-Ser/ Thr) and STn (Neu5Acα2,6GalNAcα1-Ser/Thr). However, the role of Tn and STn in cancer and other diseases is not well understood. Our recent discovery of the self-binding properties (carbohydrate- carbohydrate interactions, CCIs) of Tn (Tn-Tn) and STn (STn-STn) provides a model for their possible roles in cellular transformation. We also review evidence that Tn and STn are members of a larger family of glycan tumor antigens that possess CCIs, whichmay participate in oncogenesis.",

keywords = "Neu5Gc-GM3, Tn and STn cancer antigens, carbohydrate tumor antigens, carbohydrate-carbohydrate interactions, mechanism of action, optical tweezers",

author = "Marit Sletmoen and Gerken, {Thomas A.} and Stokke, {Bj{\o}rn T.} and Joy Burchell and Brewer, {C. Fred}",

note = "Funding Information: This work was supported in part by the National Institutes of Health grants R01CA078834 and U01GM113534 to TAG and MRC grant reference MR/ R000026/1 to JB. Publisher Copyright: {\textcopyright} 2018 Oxford University Press. All rights reserved.",

year = "2018",

month = jul,

day = "1",

doi = "10.1093/glycob/cwy032",

language = "English (US)",

volume = "28",

pages = "437--442",

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T1 - Tn and STn are members of a family of carbohydrate tumor antigens that possess carbohydrate-carbohydrate interactions

AU - Sletmoen, Marit

AU - Gerken, Thomas A.

AU - Stokke, Bjørn T.

AU - Burchell, Joy

AU - Brewer, C. Fred

N1 - Funding Information: This work was supported in part by the National Institutes of Health grants R01CA078834 and U01GM113534 to TAG and MRC grant reference MR/ R000026/1 to JB. Publisher Copyright: © 2018 Oxford University Press. All rights reserved.

PY - 2018/7/1

Y1 - 2018/7/1

N2 - The mucin-type O-glycome in cancer aberrantly expresses the truncated glycans Tn (GalNAcα1-Ser/ Thr) and STn (Neu5Acα2,6GalNAcα1-Ser/Thr). However, the role of Tn and STn in cancer and other diseases is not well understood. Our recent discovery of the self-binding properties (carbohydrate- carbohydrate interactions, CCIs) of Tn (Tn-Tn) and STn (STn-STn) provides a model for their possible roles in cellular transformation. We also review evidence that Tn and STn are members of a larger family of glycan tumor antigens that possess CCIs, whichmay participate in oncogenesis.

AB - The mucin-type O-glycome in cancer aberrantly expresses the truncated glycans Tn (GalNAcα1-Ser/ Thr) and STn (Neu5Acα2,6GalNAcα1-Ser/Thr). However, the role of Tn and STn in cancer and other diseases is not well understood. Our recent discovery of the self-binding properties (carbohydrate- carbohydrate interactions, CCIs) of Tn (Tn-Tn) and STn (STn-STn) provides a model for their possible roles in cellular transformation. We also review evidence that Tn and STn are members of a larger family of glycan tumor antigens that possess CCIs, whichmay participate in oncogenesis.

KW - Neu5Gc-GM3

KW - Tn and STn cancer antigens

KW - carbohydrate tumor antigens

KW - carbohydrate-carbohydrate interactions

KW - mechanism of action

KW - optical tweezers

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U2 - 10.1093/glycob/cwy032

DO - 10.1093/glycob/cwy032

M3 - Review article

C2 - 29618060

AN - SCOPUS:85049113855

SN - 0959-6658

VL - 28

SP - 437

EP - 442

JO - Glycobiology

JF - Glycobiology

IS - 7

ER -

Tn and STn are members of a family of carbohydrate tumor antigens that possess carbohydrate-carbohydrate interactions

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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