Titrated oxygen requirement and prognostication in idiopathic pulmonary fibrosis

J. L. Hook, S. M. Arcasoy, D. Zemmel, M. N. Bartels, S. M. Kawut, D. J. Lederer

Research output: Contribution to journalArticlepeer-review

36 Scopus citations


The supplemental oxygen flow rate is a common bedside measure of gas exchange impairment. We aimed to determine whether a titrated oxygen requirement (TOR) predicted mortality in idiopathic pulmonary fibrosis (IPF). We examined 104 adults with IPF enrolled in a prospective cohort study and a validation cohort of 151 adults with a variety of interstitial lung diseases (ILDs). The TOR was defined as the lowest oxygen flow rate required to maintain an oxyhaemoglobin saturation of 96% while standing. Cox proportional hazards models and time-dependent receiver operating characteristic curves were used to examine survival time. A higher TOR was associated with a greater mortality rate independent of forced vital capacity and 6-min walk test results in IPF (adjusted hazard ratio (per 1 L·min -1) 1.16, 95% CI 1.06-1.27). The TOR was at least as accurate as pulmonary function and 6-min walk testing at predicting 1-yr mortality. Findings were similar in other ILDs. The TOR is a simple, inexpensive bedside measurement that aids prognostication in IPF. Copyright

Original languageEnglish (US)
Pages (from-to)359-365
Number of pages7
JournalEuropean Respiratory Journal
Issue number2
StatePublished - Feb 1 2012
Externally publishedYes


  • Idiopathic pulmonary fibrosis
  • Interstitial lung diseases
  • Outcome prediction
  • Pulmonary fibrosis
  • Pulmonary gas exchange

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine


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