Title: Novel Analgesic Potential of ß2-Agonists for Neuropathic Pain via ß2-Agonist Action

Johnny P. Tran, Storm V. Horine

Research output: Contribution to journalReview articlepeer-review


Purpose of Review: Multimodal therapies are often employed to treat chronic pain, and ß2-agonists are a potential drug class that shows promise. The primary aim of this paper is to discuss the role of ß2-agonists as an adjunctive therapy for chronic pain based on the current literature. Recent Findings: Recent studies in mouse models have shown that the ß2-adrenergic system plays an essential role in the analgesic properties of antidepressant drugs used to treat neuropathic pain and that the adrenergic relies on an intact endogenous opioid system to be effective. Studies also show that ß2-agonism alone is adequate to exert anti-allodynic effects in a mouse model. Summary: This paper summarized the basic physiology and pharmacology of the sympathetic nervous system and specifically the ß2-adrenergic system and summarized current literature in its involvement in the treatment of chronic neuropathic pain.

Original languageEnglish (US)
Pages (from-to)73-77
Number of pages5
JournalCurrent pain and headache reports
Issue number1
StatePublished - Jan 2022
Externally publishedYes


  • Chronic Pain
  • Neuropathic Pain
  • ß2-Agonist Analgesia

ASJC Scopus subject areas

  • Clinical Neurology
  • Anesthesiology and Pain Medicine


Dive into the research topics of 'Title: Novel Analgesic Potential of ß2-Agonists for Neuropathic Pain via ß2-Agonist Action'. Together they form a unique fingerprint.

Cite this