Timing of neuroendocrine responses and effect of m-CPP and fenfluramine plasma levels in OCD

Eric Hollander; Lisa J. Cohen; Concetta DeCaria; Jihad B. Saoud; Dan J. Stein; Thomas B. Cooper; Nazrul N. Islam; Michael R. Liebowitz; Donald F. Klein

doi:10.1016/0006-3223(93)90186-H

Timing of neuroendocrine responses and effect of m-CPP and fenfluramine plasma levels in OCD

Eric Hollander, Lisa J. Cohen, Concetta DeCaria, Jihad B. Saoud, Dan J. Stein, Thomas B. Cooper, Nazrul N. Islam, Michael R. Liebowitz, Donald F. Klein

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

The present study assesses the timing of and relationship between neuroendocrine response and metabolite blood levels following the partial serotonin (5-HT) agonist m-CPP and the 5-HT releaser/reuptake blocker fenfluramine. Cortisol levels peaked significantly earlier than did prolactin, m-CPP, fenfluramine, or norfenfluramine blood levels by time-to-peak analysis. This earlier cortisol response to both 5-HT agents raises the possibility that peripheral mechanisms may play a role cortisol release. Since peak m-CPP level correlated even more closely to peak prolactin rise than did peak fenfluramine, this suggests that prolactin response to oral m-CPP challenge is useful in assessing 5-HT function.

Original language	English (US)
Pages (from-to)	407-413
Number of pages	7
Journal	Biological Psychiatry
Volume	34
Issue number	6
DOIs	https://doi.org/10.1016/0006-3223(93)90186-H
State	Published - Sep 15 1993
Externally published	Yes

Keywords

M-CPP
cortisol
fenfluramine
obsessive-compulsive disorder
prolactin
serotonin

ASJC Scopus subject areas

Biological Psychiatry

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10.1016/0006-3223(93)90186-H

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title = "Timing of neuroendocrine responses and effect of m-CPP and fenfluramine plasma levels in OCD",

abstract = "The present study assesses the timing of and relationship between neuroendocrine response and metabolite blood levels following the partial serotonin (5-HT) agonist m-CPP and the 5-HT releaser/reuptake blocker fenfluramine. Cortisol levels peaked significantly earlier than did prolactin, m-CPP, fenfluramine, or norfenfluramine blood levels by time-to-peak analysis. This earlier cortisol response to both 5-HT agents raises the possibility that peripheral mechanisms may play a role cortisol release. Since peak m-CPP level correlated even more closely to peak prolactin rise than did peak fenfluramine, this suggests that prolactin response to oral m-CPP challenge is useful in assessing 5-HT function.",

keywords = "M-CPP, cortisol, fenfluramine, obsessive-compulsive disorder, prolactin, serotonin",

author = "Eric Hollander and Cohen, {Lisa J.} and Concetta DeCaria and Saoud, {Jihad B.} and Stein, {Dan J.} and Cooper, {Thomas B.} and Islam, {Nazrul N.} and Liebowitz, {Michael R.} and Klein, {Donald F.}",

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AU - Hollander, Eric

AU - Cohen, Lisa J.

AU - DeCaria, Concetta

AU - Saoud, Jihad B.

AU - Stein, Dan J.

AU - Cooper, Thomas B.

AU - Islam, Nazrul N.

AU - Liebowitz, Michael R.

AU - Klein, Donald F.

PY - 1993/9/15

Y1 - 1993/9/15

N2 - The present study assesses the timing of and relationship between neuroendocrine response and metabolite blood levels following the partial serotonin (5-HT) agonist m-CPP and the 5-HT releaser/reuptake blocker fenfluramine. Cortisol levels peaked significantly earlier than did prolactin, m-CPP, fenfluramine, or norfenfluramine blood levels by time-to-peak analysis. This earlier cortisol response to both 5-HT agents raises the possibility that peripheral mechanisms may play a role cortisol release. Since peak m-CPP level correlated even more closely to peak prolactin rise than did peak fenfluramine, this suggests that prolactin response to oral m-CPP challenge is useful in assessing 5-HT function.

AB - The present study assesses the timing of and relationship between neuroendocrine response and metabolite blood levels following the partial serotonin (5-HT) agonist m-CPP and the 5-HT releaser/reuptake blocker fenfluramine. Cortisol levels peaked significantly earlier than did prolactin, m-CPP, fenfluramine, or norfenfluramine blood levels by time-to-peak analysis. This earlier cortisol response to both 5-HT agents raises the possibility that peripheral mechanisms may play a role cortisol release. Since peak m-CPP level correlated even more closely to peak prolactin rise than did peak fenfluramine, this suggests that prolactin response to oral m-CPP challenge is useful in assessing 5-HT function.

KW - M-CPP

KW - cortisol

KW - fenfluramine

KW - obsessive-compulsive disorder

KW - prolactin

KW - serotonin

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ER -

Timing of neuroendocrine responses and effect of m-CPP and fenfluramine plasma levels in OCD

Abstract

Keywords

ASJC Scopus subject areas

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