Thyroperoxidase and thyroglobulin antibodies in early pregnancy and preterm delivery

James E. Haddow, Jane Cleary-Goldman, Monica R. McClain, Glenn E. Palomaki, Louis M. Neveux, Geralyn Lambert-Messerlian, Jacob A. Canick, Fergal D. Malone, T. Flint Porter, David A. Nyberg, Peter S. Bernstein, Mary E. D'Alton

Research output: Contribution to journalArticlepeer-review

59 Scopus citations


Objective: To further evaluate the relationship between thyroid antibodies and preterm births. Methods: This is a prospective study of pregnancy outcome and demographic data combined with retrospective measurement of thyroperoxidase and thyroglobulin antibodies. Sera were obtained at 11-13 and 15-18 weeks of gestation from 10,062 women with singleton viable pregnancies (a subset from the First-and Second-Trimester Risk of Aneuploidy [FaSTER] trial). Results: Women with elevated levels of thyroperoxidase, thyroglobulin antibodies, or both in the first trimester have a higher rate of preterm delivery before 37 weeks of gestation than antibody-negative women (7.5% compared with 6.4%, odds ratio [OR] 1.18; 95% confidence interval [CI] 0.95-1.46). This is also the case for very preterm delivery before 32 weeks of gestation (1.2% compared with 0.7%, OR 1.70; 95% CI 0.98-2.94). Preterm premature rupture of membranes is also increased (2.0% compared with 1.2%, OR 1.67; 95% CI 1.05-2.44). These associations are less strong for second-trimester antibody measurements. Conclusion: The present data do not confirm strong associations between thyroid antibody elevations and preterm birth found in three of five previously published reports. Preterm premature rupture of membranes appears to contribute to the thyroid antibody-associated early deliveries, possibly as a result of inflammation.

Original languageEnglish (US)
Pages (from-to)58-62
Number of pages5
JournalObstetrics and gynecology
Issue number1
StatePublished - Jul 2010
Externally publishedYes

ASJC Scopus subject areas

  • Obstetrics and Gynecology


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