TY - JOUR
T1 - The vertebrate segmentation clock
T2 - the tip of the iceberg
AU - Özbudak, Ertuǧrul M.
AU - Pourquié, Olivier
N1 - Funding Information:
The authors thank C Gomez, A Aulehla, B Bernazeraf, and G Neto for critical reading of the manuscript. They also thank S Esteban for artwork and J Chatfield for editorial assistance. This work is supported by Stowers Institute for Medical Research. O Pourquié is a Howard Hughes Medical Institute Investigator.
PY - 2008/8
Y1 - 2008/8
N2 - The vertebrate segmentation clock was identified 10 years ago as a molecular oscillator associated with the rhythmic production of embryonic somites. Since then, three major signaling pathways - Notch, FGF, and Wnt - have been shown to be activated periodically during segmentation and proposed to constitute the clockwork of the system. However, recent results from zebrafish embryonic studies demonstrate that Notch signaling is involved in the coupling of oscillations among cells rather than in the pacemaker of the oscillator. Furthermore, genetic analyses in mouse indicate that Wnt and FGF play only a permissive role in the control of the oscillations. Therefore, the nature of the segmentation clock pacemaker still remains elusive.
AB - The vertebrate segmentation clock was identified 10 years ago as a molecular oscillator associated with the rhythmic production of embryonic somites. Since then, three major signaling pathways - Notch, FGF, and Wnt - have been shown to be activated periodically during segmentation and proposed to constitute the clockwork of the system. However, recent results from zebrafish embryonic studies demonstrate that Notch signaling is involved in the coupling of oscillations among cells rather than in the pacemaker of the oscillator. Furthermore, genetic analyses in mouse indicate that Wnt and FGF play only a permissive role in the control of the oscillations. Therefore, the nature of the segmentation clock pacemaker still remains elusive.
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U2 - 10.1016/j.gde.2008.06.007
DO - 10.1016/j.gde.2008.06.007
M3 - Review article
C2 - 18625313
AN - SCOPUS:53449089514
SN - 0959-437X
VL - 18
SP - 317
EP - 323
JO - Current Opinion in Genetics and Development
JF - Current Opinion in Genetics and Development
IS - 4
ER -