The use of DREADDs (Designer receptors exclusively activated by designer receptors) in transgenic mouse behavioral models

Daniela Cassataro; Lucas Sjulson

doi:10.1007/978-1-4939-2944-3_6

The use of DREADDs (Designer receptors exclusively activated by designer receptors) in transgenic mouse behavioral models

Daniela Cassataro, Lucas Sjulson

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Designer Receptors Exclusively Activated by Designer Drugs (DREADDs) are increasingly used to manipulate activity in specific neuronal populations in the brains of awake, behaving mice. Here we review the pros and cons of DREADDs relative to other genetically encoded neuromodulation technologies and describe in detail methods for using DREADDs with transgenic mouse behavioral models. This approach can not only provide insight into the role of specific neural circuits in behavior but also identify potential neuromodulation targets for the treatment of neuropsychiatric disorders.

Original language	English (US)
Pages (from-to)	95-108
Number of pages	14
Journal	Neuromethods
Volume	108
DOIs	https://doi.org/10.1007/978-1-4939-2944-3_6
State	Published - 2015
Externally published	Yes

Keywords

Addiction
CNO
DREADDs
Mouse behavior
Reverse pharmacogenetics
Transgenic mice

ASJC Scopus subject areas

Psychiatry and Mental health
General Pharmacology, Toxicology and Pharmaceutics
General Biochemistry, Genetics and Molecular Biology
General Neuroscience

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/978-1-4939-2944-3_6

Cite this

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title = "The use of DREADDs (Designer receptors exclusively activated by designer receptors) in transgenic mouse behavioral models",

abstract = "Designer Receptors Exclusively Activated by Designer Drugs (DREADDs) are increasingly used to manipulate activity in specific neuronal populations in the brains of awake, behaving mice. Here we review the pros and cons of DREADDs relative to other genetically encoded neuromodulation technologies and describe in detail methods for using DREADDs with transgenic mouse behavioral models. This approach can not only provide insight into the role of specific neural circuits in behavior but also identify potential neuromodulation targets for the treatment of neuropsychiatric disorders.",

keywords = "Addiction, CNO, DREADDs, Mouse behavior, Reverse pharmacogenetics, Transgenic mice",

author = "Daniela Cassataro and Lucas Sjulson",

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AU - Sjulson, Lucas

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PY - 2015

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AB - Designer Receptors Exclusively Activated by Designer Drugs (DREADDs) are increasingly used to manipulate activity in specific neuronal populations in the brains of awake, behaving mice. Here we review the pros and cons of DREADDs relative to other genetically encoded neuromodulation technologies and describe in detail methods for using DREADDs with transgenic mouse behavioral models. This approach can not only provide insight into the role of specific neural circuits in behavior but also identify potential neuromodulation targets for the treatment of neuropsychiatric disorders.

KW - Addiction

KW - CNO

KW - DREADDs

KW - Mouse behavior

KW - Reverse pharmacogenetics

KW - Transgenic mice

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The use of DREADDs (Designer receptors exclusively activated by designer receptors) in transgenic mouse behavioral models

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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