TY - JOUR
T1 - The transmission/disequilibrium test for linkage on the X chromosome
AU - Ho, Gloria Y.F.
AU - Bailey-Wilson, Joan E.
PY - 2000
Y1 - 2000
N2 - The transmission/disequilibrium test (TDT), which detects linkage between a marker and disease loci in the presence of linkage disequilibrium, was introduced by Spielman et al. The original TDT requires families in which the genotypes are known for both parents and for at least one affected offspring, and this limits its applicability to diseases with late onset. The sib-TDT, or S-TDT, which utilizes families with affected and unaffected siblings, was introduced as an alternative method, by Spielman and Ewens, and the TDT and S-TDT can be combined in an overall test (i.e., a combined-TDT, or C-TDT). The TDT statistics described so far are for autosomal chromosomes. We have extended these TDT methods to test for linkage between X-linked markers and diseases that affect either males only or both sexes. For diseases of late onset, when parental genotypes are often unavailable, the X- linkage C-TDT may allow for more power than is provided by the X-linkage TDT alone.
AB - The transmission/disequilibrium test (TDT), which detects linkage between a marker and disease loci in the presence of linkage disequilibrium, was introduced by Spielman et al. The original TDT requires families in which the genotypes are known for both parents and for at least one affected offspring, and this limits its applicability to diseases with late onset. The sib-TDT, or S-TDT, which utilizes families with affected and unaffected siblings, was introduced as an alternative method, by Spielman and Ewens, and the TDT and S-TDT can be combined in an overall test (i.e., a combined-TDT, or C-TDT). The TDT statistics described so far are for autosomal chromosomes. We have extended these TDT methods to test for linkage between X-linked markers and diseases that affect either males only or both sexes. For diseases of late onset, when parental genotypes are often unavailable, the X- linkage C-TDT may allow for more power than is provided by the X-linkage TDT alone.
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U2 - 10.1086/302822
DO - 10.1086/302822
M3 - Article
C2 - 10712228
AN - SCOPUS:0033940030
SN - 0002-9297
VL - 66
SP - 1158
EP - 1160
JO - American Journal of Human Genetics
JF - American Journal of Human Genetics
IS - 3
ER -