TY - JOUR
T1 - The therapeutic effects of berberine for gastrointestinal cancers
AU - Davoodvandi, Amirhossein
AU - Sadeghi, Sahand
AU - Alavi, Seyed Mohammad Amin
AU - Alavi, Seyedeh Shaghayegh
AU - Jafari, Ameneh
AU - Khan, Haroon
AU - Aschner, Michael
AU - Mirzaei, Hamed
AU - Sharifi, Mehran
AU - Asemi, Zatollah
N1 - Publisher Copyright:
© 2023 The Authors. Asia-Pacific Journal of Clinical Oncology published by John Wiley & Sons Australia, Ltd.
PY - 2024/4
Y1 - 2024/4
N2 - Cancer is one of the most serious human health issues. Drug therapy is the major common way to treat cancer. There is a growing interest in using natural compounds to overcome drug resistance, adverse reactions, and target specificity of certain types of drugs that may affect several targets with fewer side effects and be beneficial against various types of cancer. In this regard, the use of herbal medicines alone or in combination with the main anticancer drugs is commonly available. Berberine (BBR), a nature-driven phytochemical component, is a well-known nutraceutical due to its wide variety of pharmacological activities, including antioxidant, anti-inflammatory, antibacterial, antifungal, antiparasitic, antidiabetic, antihypertensive, and hypolipidemic. In addition, BBR exerts anticancer activities. In present article, we summarized the information available on the therapeutic effects of BBR and its mechanisms on five types of the most prevalent gastrointestinal cancers, including esophageal, gastric, colorectal, hepatocarcinoma, and pancreatic cancers.
AB - Cancer is one of the most serious human health issues. Drug therapy is the major common way to treat cancer. There is a growing interest in using natural compounds to overcome drug resistance, adverse reactions, and target specificity of certain types of drugs that may affect several targets with fewer side effects and be beneficial against various types of cancer. In this regard, the use of herbal medicines alone or in combination with the main anticancer drugs is commonly available. Berberine (BBR), a nature-driven phytochemical component, is a well-known nutraceutical due to its wide variety of pharmacological activities, including antioxidant, anti-inflammatory, antibacterial, antifungal, antiparasitic, antidiabetic, antihypertensive, and hypolipidemic. In addition, BBR exerts anticancer activities. In present article, we summarized the information available on the therapeutic effects of BBR and its mechanisms on five types of the most prevalent gastrointestinal cancers, including esophageal, gastric, colorectal, hepatocarcinoma, and pancreatic cancers.
KW - berberine
KW - gastrointestinal cancer
KW - therapy
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U2 - 10.1111/ajco.13941
DO - 10.1111/ajco.13941
M3 - Review article
C2 - 36915942
AN - SCOPUS:85150618611
SN - 1743-7555
VL - 20
SP - 152
EP - 167
JO - Asia-Pacific Journal of Clinical Oncology
JF - Asia-Pacific Journal of Clinical Oncology
IS - 2
ER -