The Sphenopalatine Ganglion: Anatomy, Pathophysiology, and Therapeutic Targeting in Headache

Matthew S. Robbins, Carrie E. Robertson, Eugene Kaplan, Jessica Ailani, Larry Charleston, Deena Kuruvilla, Andrew Blumenfeld, Randall Berliner, Noah L. Rosen, Robert Duarte, Jaskiran Vidwan, Rashmi B. Halker, Nicole Gill, Avi Ashkenazi

Research output: Contribution to journalReview articlepeer-review

105 Scopus citations


The sphenopalatine ganglion (SPG) has attracted the interest of practitioners treating head and face pain for over a century because of its anatomical connections and role in the trigemino-autonomic reflex. In this review, we discuss the anatomy of the SPG, as well as what is known about its role in the pathophysiology of headache disorders, including cluster headache and migraine. We then address various therapies that target the SPG, including intranasal medication delivery, new SPG blocking catheter devices, neurostimulation, chemical neurolysis, and ablation procedures.

Original languageEnglish (US)
Pages (from-to)240-258
Number of pages19
Issue number2
StatePublished - Feb 1 2016


  • ablation
  • cluster
  • ganglion
  • headache
  • migraine
  • neuralgia
  • neurostimulation
  • pterygopalatine
  • sphenopalatine

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology


Dive into the research topics of 'The Sphenopalatine Ganglion: Anatomy, Pathophysiology, and Therapeutic Targeting in Headache'. Together they form a unique fingerprint.

Cite this