TY - JOUR
T1 - The significance of fractionation regimens in radiation and combined hyperthermia using a murine fibrosarcoma
AU - Hahn, Eric W.
AU - Alfieri, Alan A.
AU - Kim, Jae Ho
PY - 1978/12
Y1 - 1978/12
N2 - The significance of time‐dose relationships in the use of local tumor hyperthermia (LTH) when combined with radiation (RAD) was studied in a murine fibrosarcoma. RAD, either alone or combined with LTH, was delivered in four equal fractions (total doses, 1.8 to 4.2 krad) separated by 1 to 4 days. LTH (43.1 C ± .05 C for 15 minutes, water bath) was applied immediately after RAD. In this tumor system, RAD was most effective when delivered every 2nd or 3rd day, by a factor of 1.25 over the response achieved when the four fractions were delivered every 1 or 4 days. At all levels studied, RAD + LTH produced a superior tumor response compared to RAD alone. The ratio of the RAD + LTH/RAD doses to achieve an isobiological response ranged from 1.7 to 2.5. Most significant was the finding that the RAD + LTH treatment response was independent of the fractionation scheme used and more dependent on the total RAD dose delivered. Cancer 42:2596–2599, 1978.
AB - The significance of time‐dose relationships in the use of local tumor hyperthermia (LTH) when combined with radiation (RAD) was studied in a murine fibrosarcoma. RAD, either alone or combined with LTH, was delivered in four equal fractions (total doses, 1.8 to 4.2 krad) separated by 1 to 4 days. LTH (43.1 C ± .05 C for 15 minutes, water bath) was applied immediately after RAD. In this tumor system, RAD was most effective when delivered every 2nd or 3rd day, by a factor of 1.25 over the response achieved when the four fractions were delivered every 1 or 4 days. At all levels studied, RAD + LTH produced a superior tumor response compared to RAD alone. The ratio of the RAD + LTH/RAD doses to achieve an isobiological response ranged from 1.7 to 2.5. Most significant was the finding that the RAD + LTH treatment response was independent of the fractionation scheme used and more dependent on the total RAD dose delivered. Cancer 42:2596–2599, 1978.
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U2 - 10.1002/1097-0142(197812)42:6<2596::AID-CNCR2820420613>3.0.CO;2-I
DO - 10.1002/1097-0142(197812)42:6<2596::AID-CNCR2820420613>3.0.CO;2-I
M3 - Article
C2 - 728862
AN - SCOPUS:0018216051
SN - 0008-543X
VL - 42
SP - 2596
EP - 2599
JO - Cancer
JF - Cancer
IS - 6
ER -
