TY - JOUR
T1 - The role of selenium in intestinal motility and morphology in a murine model of Typanosoma cruzi infection
AU - De Souza, Andréa Pereira
AU - Sieberg, Ryan
AU - Li, Hua
AU - Cahill, Hannah R.
AU - Zhao, Dazhi
AU - Araújo-Jorge, Tania C.
AU - Tanowitz, Herbert B.
AU - Jelicks, Linda A.
N1 - Funding Information:
Acknowledgment This work was supported in part by grants from the Unites States National Institute of Health grants CA123334 and AI062730 (LAJ) and AI076248 (HBT), Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), Coordenação de Aperfeiçoamento de Pessoal de Ensino Superior (CAPES), FIOC-RUZ, and FAPERJ. All animal studies were performed in accordance with the guidelines established by the Institutional Animal Care and Use Committee of the Albert Einstein College of Medicine.
PY - 2010/5
Y1 - 2010/5
N2 - Infection with Trypanosoma cruzi causes megasyndromes of the gastrointestinal (GI) tract in humans and animals. In the present study, we employed magnetic resonance imaging to non-invasively monitor the effect of selenium supplementation on alterations in the GI tract of T. cruzi-infected mice. CD1 mice infected with T. cruzi (Brazil strain) exhibited dilatation of the intestines similar to that we recently reported in infected C57Bl/6 mice. The average intestine lumen diameter increased by 65% and the increase was reduced to 29% in mice supplemented with 2 ppm selenium in the drinking water. When supplemented with 3 ppm selenium in chow the lumen diameter was also significantly reduced although the difference between the infected and infected supplemented mice was smaller. Intestinal motility in infected mice fed with selenium-enriched chow was increased compared with infected mice fed with normal unsupplemented chow and was not significantly different from intestinal motility in uninfected mice. We suggest that Se may be used to modulate the inflammatory, immunological, and/or antioxidant responses involved in intestinal disturbances caused by T. cruzi infection.
AB - Infection with Trypanosoma cruzi causes megasyndromes of the gastrointestinal (GI) tract in humans and animals. In the present study, we employed magnetic resonance imaging to non-invasively monitor the effect of selenium supplementation on alterations in the GI tract of T. cruzi-infected mice. CD1 mice infected with T. cruzi (Brazil strain) exhibited dilatation of the intestines similar to that we recently reported in infected C57Bl/6 mice. The average intestine lumen diameter increased by 65% and the increase was reduced to 29% in mice supplemented with 2 ppm selenium in the drinking water. When supplemented with 3 ppm selenium in chow the lumen diameter was also significantly reduced although the difference between the infected and infected supplemented mice was smaller. Intestinal motility in infected mice fed with selenium-enriched chow was increased compared with infected mice fed with normal unsupplemented chow and was not significantly different from intestinal motility in uninfected mice. We suggest that Se may be used to modulate the inflammatory, immunological, and/or antioxidant responses involved in intestinal disturbances caused by T. cruzi infection.
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U2 - 10.1007/s00436-010-1794-1
DO - 10.1007/s00436-010-1794-1
M3 - Article
C2 - 20195635
AN - SCOPUS:77953325712
SN - 0932-0113
VL - 106
SP - 1293
EP - 1298
JO - Parasitology research
JF - Parasitology research
IS - 6
ER -
