The role of brain-derived neurotrophic factor in neural circuit development and function

Anita E. Autry, Dhananjay Bambah-Mukku

Research output: Chapter in Book/Report/Conference proceedingChapter

4 Scopus citations


Brain-derived neurotrophic factor (BDNF) is a key molecule involved in various aspects of neuronal circuit development and function. In this chapter, we will first discuss the complex transcriptional and translational regulation of BDNF, its secretion, and receptor-mediated actions at pre-and postsynaptic sites. Next, we will cover how those functions affect neural circuit development and maturation. Finally, we will highlight a selection of important findings regarding the role of BDNF in the context of specific neural circuits affecting normal behavior and disease, though this section is by no means an exhaustive treatment of the findings regarding BDNF.

Original languageEnglish (US)
Title of host publicationSynapse Development and Maturation
Subtitle of host publicationComprehensive Developmental Neuroscience
Number of pages24
ISBN (Electronic)9780128236727
StatePublished - Jan 1 2020


  • Alzheimer’s disease
  • Amygdala
  • BDNF
  • Cortex
  • Depression
  • Development
  • Fragile X syndrome
  • Hippocampus
  • Huntington’s disease
  • LTP
  • Learning
  • MeCP2
  • Memory
  • NMDA receptors
  • Neurogenesis
  • Nucleus accumbens
  • Rett syndrome
  • Stress
  • Synaptic plasticity

ASJC Scopus subject areas

  • General Neuroscience


Dive into the research topics of 'The role of brain-derived neurotrophic factor in neural circuit development and function'. Together they form a unique fingerprint.

Cite this