The role of brain-derived neurotrophic factor in neural circuit development and function

Anita E. Autry; Dhananjay Bambah-Mukku

doi:10.1016/B978-0-12-823672-7.00020-X

The role of brain-derived neurotrophic factor in neural circuit development and function

Anita E. Autry, Dhananjay Bambah-Mukku

Neuroscience

Research output: Chapter in Book/Report/Conference proceeding › Chapter

4 Scopus citations

Abstract

Brain-derived neurotrophic factor (BDNF) is a key molecule involved in various aspects of neuronal circuit development and function. In this chapter, we will first discuss the complex transcriptional and translational regulation of BDNF, its secretion, and receptor-mediated actions at pre-and postsynaptic sites. Next, we will cover how those functions affect neural circuit development and maturation. Finally, we will highlight a selection of important findings regarding the role of BDNF in the context of specific neural circuits affecting normal behavior and disease, though this section is by no means an exhaustive treatment of the findings regarding BDNF.

Original language	English (US)
Title of host publication	Synapse Development and Maturation
Subtitle of host publication	Comprehensive Developmental Neuroscience
Publisher	Elsevier
Pages	443-466
Number of pages	24
ISBN (Electronic)	9780128236727
DOIs	https://doi.org/10.1016/B978-0-12-823672-7.00020-X
State	Published - Jan 1 2020

Keywords

Alzheimer’s disease
Amygdala
BDNF
Cortex
Depression
Development
Fragile X syndrome
Hippocampus
Huntington’s disease
LTP
Learning
MeCP2
Memory
NMDA receptors
Neurogenesis
Nucleus accumbens
Rett syndrome
Stress
Synaptic plasticity

ASJC Scopus subject areas

General Neuroscience

Access to Document

10.1016/B978-0-12-823672-7.00020-X

Cite this

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title = "The role of brain-derived neurotrophic factor in neural circuit development and function",

abstract = "Brain-derived neurotrophic factor (BDNF) is a key molecule involved in various aspects of neuronal circuit development and function. In this chapter, we will first discuss the complex transcriptional and translational regulation of BDNF, its secretion, and receptor-mediated actions at pre-and postsynaptic sites. Next, we will cover how those functions affect neural circuit development and maturation. Finally, we will highlight a selection of important findings regarding the role of BDNF in the context of specific neural circuits affecting normal behavior and disease, though this section is by no means an exhaustive treatment of the findings regarding BDNF.",

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AU - Bambah-Mukku, Dhananjay

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N2 - Brain-derived neurotrophic factor (BDNF) is a key molecule involved in various aspects of neuronal circuit development and function. In this chapter, we will first discuss the complex transcriptional and translational regulation of BDNF, its secretion, and receptor-mediated actions at pre-and postsynaptic sites. Next, we will cover how those functions affect neural circuit development and maturation. Finally, we will highlight a selection of important findings regarding the role of BDNF in the context of specific neural circuits affecting normal behavior and disease, though this section is by no means an exhaustive treatment of the findings regarding BDNF.

AB - Brain-derived neurotrophic factor (BDNF) is a key molecule involved in various aspects of neuronal circuit development and function. In this chapter, we will first discuss the complex transcriptional and translational regulation of BDNF, its secretion, and receptor-mediated actions at pre-and postsynaptic sites. Next, we will cover how those functions affect neural circuit development and maturation. Finally, we will highlight a selection of important findings regarding the role of BDNF in the context of specific neural circuits affecting normal behavior and disease, though this section is by no means an exhaustive treatment of the findings regarding BDNF.

KW - Alzheimer’s disease

KW - Amygdala

KW - BDNF

KW - Cortex

KW - Depression

KW - Development

KW - Fragile X syndrome

KW - Hippocampus

KW - Huntington’s disease

KW - LTP

KW - Learning

KW - MeCP2

KW - Memory

KW - NMDA receptors

KW - Neurogenesis

KW - Nucleus accumbens

KW - Rett syndrome

KW - Stress

KW - Synaptic plasticity

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SP - 443

EP - 466

BT - Synapse Development and Maturation

PB - Elsevier

ER -

The role of brain-derived neurotrophic factor in neural circuit development and function

Abstract

Keywords

ASJC Scopus subject areas

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