The role of B cells and humoral immunity in Mycobacterium tuberculosis infection

John Chan, Simren Mehta, Sushma Bharrhan, Yong Chen, Jacqueline M. Achkar, Arturo Casadevall, Jo Anne Flynn

Research output: Contribution to journalReview articlepeer-review

115 Scopus citations


Mycobacterium tuberculosis remains a major public health burden. It is generally thought that while B cell-and antibody-mediated immunity plays an important role in host defense against extracellular pathogens, the primary control of intracellular microbes derives from cellular immune mechanisms. Studies on the immune regulatory mechanisms during infection with M. tuberculosis, a facultative intracellular organism, has established the importance of cell-mediated immunity in host defense during tuberculous infection. Emerging evidence suggest a role for B cell and humoral immunity in the control of intracellular pathogens, including obligatory species, through interactions with the cell-mediated immune compartment. Recent studies have shown that B cells and antibodies can significantly impact on the development of immune responses to the tubercle bacillus. In this review, we present experimental evidence supporting the notion that the importance of humoral and cellular immunity in host defense may not be entirely determined by the niche of the pathogen. A comprehensive approach that examines both humoral and cellular immunity could lead to better understanding of the immune response to M. tuberculosis.

Original languageEnglish (US)
Pages (from-to)588-600
Number of pages13
JournalSeminars in Immunology
Issue number6
StatePublished - Dec 1 2014


  • Antibodies
  • B cells
  • FcγR
  • Mycobacterium tuberculosis
  • Tuberculosis

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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