The nonelectrolyte permeability of planar lipid bilayer membranes

Eli Orbach, Alan Finkelstein

Research output: Contribution to journalArticlepeer-review

120 Scopus citations


The permeability of lecithin bilayer membranes to nonelectrolytes is in reasonable agreement with Overton’s rule. That is, Pd α DKhc, where Pd is the permeability coeffieient of a solute through the bilayer, Khc is its hydrocarbon: water partition coefficient, and D is its diffusion coefficient in bulk hydrocarbon. The partition coefficients are by far the major determinants of the relative magnitudes of the permeability coefficients; the diffusion coefficients make only a minor contribution. We note that the recent emphasis on theoretically calculated intramembranous diffusion coefficients (Din’s) has diverted attention from the experimentally measureable and physiologically relevant permeability coefficients (Pd’S) and has obscured the simplicity and usefulness of Overton’s rule.

Original languageEnglish (US)
Pages (from-to)403-426
Number of pages24
JournalJournal of General Physiology
Issue number4
StatePublished - Apr 1 1980
Externally publishedYes

ASJC Scopus subject areas

  • Physiology


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