The neuroanatomy of 5-HT dysregulation and panic disorder

Gregory Grove, Jeremy D. Coplan, Eric Hollander

Research output: Contribution to journalReview articlepeer-review

57 Scopus citations


The advent of highly effective antipanic medications with specific serotonin reuptake inhibition as a mechanism of action has prompted the need for new pathophysiological models of panic disorder. The authors attempt an integration of the emerging basic science literature regarding the neuroanatomy and physiology of the mammalian central serotonin nervous system, its influence an neural substrates that underlie fear and defense responses, and the clinical literature pertaining to serotonin-related abnormalities in panic disorder. A neuroanatomical model for the potential sites of action of the specific serotonin reuptake inhibitors in panic disorder is proposed.

Original languageEnglish (US)
Pages (from-to)198-207
Number of pages10
JournalJournal of Neuropsychiatry and Clinical Neurosciences
Issue number2
StatePublished - 1997
Externally publishedYes

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health


Dive into the research topics of 'The neuroanatomy of 5-HT dysregulation and panic disorder'. Together they form a unique fingerprint.

Cite this