Abstract
The mechanisms that move chromatids poleward during anaphase A have fascinated researchers for decades. There is now growing evidence that this movement is tightly linked to the active depolymerization of both ends of kinetochore-associated microtubules, a mechanism we refer to as "Pacman-Flux." Contemporary data suggest that this is catalyzed by the integration of multiple enzymatic activities including (1) microtubule-end depoly-merases housed at the pole or kinetochore, (2) microtubule-severing enzymes used to uncap the ends of kinetochore-associated microtubules, and (3) molecular motors which drive tubulins towards the pole or into kinetochores.
Original language | English (US) |
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Pages (from-to) | 423-432 |
Number of pages | 10 |
Journal | Chromosome Research |
Volume | 19 |
Issue number | 3 |
DOIs | |
State | Published - Apr 2011 |
Keywords
- Anaphase A
- Mitosis
- Pacman
- Poleward flux
- Spindle
ASJC Scopus subject areas
- Genetics