The mitochondrial death pathway and cardiac myocyte apoptosis

Michael T. Crow, Kartik Mani, Young Jae Nam, Richard N. Kitsis

Research output: Contribution to journalReview articlepeer-review

503 Scopus citations


Apoptosis has been causally linked to the pathogenesis of myocardial infarction and heart failure in rodent models. This death process is mediated by two central pathways, an extrinsic pathway involving cell surface receptors and an intrinsic pathway using mitochondria and the endoplasmic reticulum. Each of these pathways has been implicated in myocardial pathology. In this review, we summarize recent advances in the understanding of the intrinsic pathway and how it relates to cardiac myocyte death and heart disease.

Original languageEnglish (US)
Pages (from-to)957-970
Number of pages14
JournalCirculation research
Issue number10
StatePublished - Nov 12 2004


  • Apoptosis
  • Apoptosome
  • Bcl-2
  • Caspase
  • Cell death
  • Death-inducing signaling complex
  • Heart failure
  • Ischemia
  • Mitochondria
  • Necrosis

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine


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