The Mini-Mental State Examination among adult outpatients with major depressive disorder

J. E. Alpert, L. A. Uebelacker, N. E. McLean, M. Abraham, J. F. Rosenbaum, M. Fava

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


One hundred forty-eight patients, ages 18-65, with major depression were administered the Mini-Mental State Examination (MMSE) prior to 8 weeks of treatment with fluoxetine; 75 of these patients were readministered the MMSE following treatment. MMSE scores were not related to pretreatment severity of depression or to reported concentration problems and were not predictive of antidepressant response. Non- and partial responders had lower posttreatment MMSE scores than responders, men had lower posttreatment scores than women, and subjects over 50 had lower pretreatment scores than younger subjects, although in all cases, the magnitude of the differences was small and unlikely to be clinically important. Our results suggest that while the MMSE has been shown to be useful among geriatric and other depressed inpatients, it is not a sensitive indicator of depression severity, concentration problems, or likelihood of treatment response among otherwise healthy adults with major depression in an outpatient setting.

Original languageEnglish (US)
Pages (from-to)207-211
Number of pages5
JournalPsychotherapy and Psychosomatics
Issue number3-4
StatePublished - 1995
Externally publishedYes


  • Cognition
  • Depression
  • Fluoxetine
  • Mini-Mental State Examination
  • Neuropsychiatric testing

ASJC Scopus subject areas

  • Clinical Psychology
  • Applied Psychology
  • Psychiatry and Mental health


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