The intricate regulation and complex functions of the Class III phosphoinositide 3-kinase Vps34

Jonathan M. Backer

doi:10.1042/BCJ20160170

The intricate regulation and complex functions of the Class III phosphoinositide 3-kinase Vps34

Jonathan M. Backer

Molecular Pharmacology

Research output: Contribution to journal › Review article › peer-review

157 Scopus citations

Abstract

The Class III phosphoinositide 3-kinase Vps34 (vacuolar protein sorting 34) plays important roles in endocytic trafficking, macroautophagy, phagocytosis, cytokinesis and nutrient sensing. Recent studies have provided exciting new insights into the structure and regulation of this lipid kinase, and new cellular functions for Vps34 have emerged. This review critically examines the wealth of new data on this important enzyme, and attempts to integrate these findings with current models of Vps34 signalling.

Original language	English (US)
Pages (from-to)	2251-2271
Number of pages	21
Journal	Biochemical Journal
Volume	473
Issue number	15
DOIs	https://doi.org/10.1042/BCJ20160170
State	Published - 2016

Keywords

Autophagy
Class III phosphoinositide 3-kinase
Endocytosis
Phosphoinositide 3-kinase
Phosphorylation/ dephosphorylation
Vps34

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

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10.1042/BCJ20160170

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abstract = "The Class III phosphoinositide 3-kinase Vps34 (vacuolar protein sorting 34) plays important roles in endocytic trafficking, macroautophagy, phagocytosis, cytokinesis and nutrient sensing. Recent studies have provided exciting new insights into the structure and regulation of this lipid kinase, and new cellular functions for Vps34 have emerged. This review critically examines the wealth of new data on this important enzyme, and attempts to integrate these findings with current models of Vps34 signalling.",

keywords = "Autophagy, Class III phosphoinositide 3-kinase, Endocytosis, Phosphoinositide 3-kinase, Phosphorylation/ dephosphorylation, Vps34",

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AB - The Class III phosphoinositide 3-kinase Vps34 (vacuolar protein sorting 34) plays important roles in endocytic trafficking, macroautophagy, phagocytosis, cytokinesis and nutrient sensing. Recent studies have provided exciting new insights into the structure and regulation of this lipid kinase, and new cellular functions for Vps34 have emerged. This review critically examines the wealth of new data on this important enzyme, and attempts to integrate these findings with current models of Vps34 signalling.

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The intricate regulation and complex functions of the Class III phosphoinositide 3-kinase Vps34

Abstract

Keywords

ASJC Scopus subject areas

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