The interaction between microglia and neural stem/precursor cells

Peng Su; Jianbin Zhang; Fang Zhao; Michael Aschner; Jingyuan Chen; Wenjing Luo

doi:10.1016/j.brainresbull.2014.09.005

The interaction between microglia and neural stem/precursor cells

Peng Su, Jianbin Zhang, Fang Zhao, Michael Aschner, Jingyuan Chen, Wenjing Luo

Molecular Pharmacology

Research output: Contribution to journal › Review article › peer-review

40 Scopus citations

Abstract

In the adult mammalian brain, neurogenesis from neural stem/precursor cell occurs within two regions, the subgranular zone (SGZ) in the dentate gyrus (DG) and the subventricular zone (SVZ) lining the lateral ventricles. The function of neural stem cell is enhanced by external stimuli, such as injury and inflammation. Microglia, as the main immune modulating cells, play important roles in the central nervous system (CNS). Recently, select discoveries reported that microglia might influence the proliferation, differentiation and survival of neural precursor cells (NPCs). Other studies revealed that NPCs might reversibly regulate the function of microglia. Accordingly, in this review we focus on the interaction between microglia and NPCs.

Original language	English (US)
Pages (from-to)	32-38
Number of pages	7
Journal	Brain Research Bulletin
Volume	109
DOIs	https://doi.org/10.1016/j.brainresbull.2014.09.005
State	Published - 2014

Keywords

Coculture
Microglia
Neural stem/precursor cells
Neurogenesis

ASJC Scopus subject areas

Neuroscience(all)

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10.1016/j.brainresbull.2014.09.005

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title = "The interaction between microglia and neural stem/precursor cells",

abstract = "In the adult mammalian brain, neurogenesis from neural stem/precursor cell occurs within two regions, the subgranular zone (SGZ) in the dentate gyrus (DG) and the subventricular zone (SVZ) lining the lateral ventricles. The function of neural stem cell is enhanced by external stimuli, such as injury and inflammation. Microglia, as the main immune modulating cells, play important roles in the central nervous system (CNS). Recently, select discoveries reported that microglia might influence the proliferation, differentiation and survival of neural precursor cells (NPCs). Other studies revealed that NPCs might reversibly regulate the function of microglia. Accordingly, in this review we focus on the interaction between microglia and NPCs.",

keywords = "Coculture, Microglia, Neural stem/precursor cells, Neurogenesis",

author = "Peng Su and Jianbin Zhang and Fang Zhao and Michael Aschner and Jingyuan Chen and Wenjing Luo",

note = "Funding Information: This work was supported by the National Basic Research Program of China ( 2012CD525004 ), National Key Technology Support Program ( 2014BAI12B04 ), National Scientific Foundation of China ( 81230063, 81273101, 81302451 ), Program for Changjiang Scholars ( T2011153 ) and Innovative Research Team in University (PCSIRT), Shaanxi science and technology coordinating innovative project ( 2011KTCL03-19 ) and in part by grants from the National Institutes of Health ( R01 ES 010563, R01 ES 007331 and R01 ES 020852 (MA). Publisher Copyright: {\textcopyright} 2014 Elsevier Inc.",

year = "2014",

doi = "10.1016/j.brainresbull.2014.09.005",

language = "English (US)",

volume = "109",

pages = "32--38",

journal = "Brain Research Bulletin",

issn = "0361-9230",

publisher = "Elsevier Inc.",

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T1 - The interaction between microglia and neural stem/precursor cells

AU - Su, Peng

AU - Zhang, Jianbin

AU - Zhao, Fang

AU - Aschner, Michael

AU - Chen, Jingyuan

AU - Luo, Wenjing

N1 - Funding Information: This work was supported by the National Basic Research Program of China ( 2012CD525004 ), National Key Technology Support Program ( 2014BAI12B04 ), National Scientific Foundation of China ( 81230063, 81273101, 81302451 ), Program for Changjiang Scholars ( T2011153 ) and Innovative Research Team in University (PCSIRT), Shaanxi science and technology coordinating innovative project ( 2011KTCL03-19 ) and in part by grants from the National Institutes of Health ( R01 ES 010563, R01 ES 007331 and R01 ES 020852 (MA). Publisher Copyright: © 2014 Elsevier Inc.

PY - 2014

Y1 - 2014

N2 - In the adult mammalian brain, neurogenesis from neural stem/precursor cell occurs within two regions, the subgranular zone (SGZ) in the dentate gyrus (DG) and the subventricular zone (SVZ) lining the lateral ventricles. The function of neural stem cell is enhanced by external stimuli, such as injury and inflammation. Microglia, as the main immune modulating cells, play important roles in the central nervous system (CNS). Recently, select discoveries reported that microglia might influence the proliferation, differentiation and survival of neural precursor cells (NPCs). Other studies revealed that NPCs might reversibly regulate the function of microglia. Accordingly, in this review we focus on the interaction between microglia and NPCs.

AB - In the adult mammalian brain, neurogenesis from neural stem/precursor cell occurs within two regions, the subgranular zone (SGZ) in the dentate gyrus (DG) and the subventricular zone (SVZ) lining the lateral ventricles. The function of neural stem cell is enhanced by external stimuli, such as injury and inflammation. Microglia, as the main immune modulating cells, play important roles in the central nervous system (CNS). Recently, select discoveries reported that microglia might influence the proliferation, differentiation and survival of neural precursor cells (NPCs). Other studies revealed that NPCs might reversibly regulate the function of microglia. Accordingly, in this review we focus on the interaction between microglia and NPCs.

KW - Coculture

KW - Microglia

KW - Neural stem/precursor cells

KW - Neurogenesis

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DO - 10.1016/j.brainresbull.2014.09.005

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VL - 109

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JO - Brain Research Bulletin

JF - Brain Research Bulletin

ER -

The interaction between microglia and neural stem/precursor cells

Abstract

Keywords

ASJC Scopus subject areas

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