The influence of pregnancy on human immunodeficiency virus type 1 infection: Antepartum and postpartum changes in human immunodeficiency virus type 1 viral load

D. N. Burns; S. Landesman; H. Minkoff; D. J. Wright; D. Waters; R. M. Mitchell; A. Rubinstein; A. Willoughby; J. J. Goedert

doi:10.1016/S0002-9378(98)80025-2

The influence of pregnancy on human immunodeficiency virus type 1 infection: Antepartum and postpartum changes in human immunodeficiency virus type 1 viral load

D. N. Burns, S. Landesman, H. Minkoff, D. J. Wright, D. Waters, R. M. Mitchell, A. Rubinstein, A. Willoughby, J. J. Goedert

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

OBJECTIVE: Our objective was to examine the influence of pregnancy on human immunodeficiency virus type 1 viral lead by measuring human immunodeficiency virus type 1 ribonucleic acid levels during pregnancy and post partum. STUDY DESIGN: One or more plasma or serum specimens obtained before and during the third trimester, and at 2, 12, and 24 months post partum were available for 160 human immunodeficiency virus type 1- seropositive women enrolled in the Mothers and Infants Cohort Study between January 1986 and January 1991. All specimens were frozen and stored at - 70°C until analyzed in batch for human immunodeficiency virus type 1 ribonucleic acid by polymerase chain reaction. A multivariate longitudinal random effects model was developed to examine changes in human immunodeficiency virus type 1 ribonucleic acid levels over time. RESULTS: Overall, human immunodeficiency virus type 1 ribonucleic acid levels rose significantly during the study period, particularly during the second year post partum (mean, 0.09 log per year; 95% confidence interval, 0.03 to 0.15 logs per year; p = 0.005). However, the mean slope during pregnancy was not significantly different from zero (p = 0.65). CONCLUSION: Pregnancy had little immediate effect on human immunodeficiency virus type l viral lead in most human immunodeficiency virus type 1-seropositive women.

Original language	English (US)
Pages (from-to)	355-359
Number of pages	5
Journal	American journal of obstetrics and gynecology
Volume	178
Issue number	2
DOIs	https://doi.org/10.1016/S0002-9378(98)80025-2
State	Published - 1998
Externally published	Yes

Keywords

Acquired immunodeficiency syndrome
Human immunodeficiency virus
Pregnancy
Ribonucleic acid
Virus

ASJC Scopus subject areas

Obstetrics and Gynecology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/S0002-9378(98)80025-2

Cite this

Burns, D. N., Landesman, S., Minkoff, H., Wright, D. J., Waters, D., Mitchell, R. M., Rubinstein, A., Willoughby, A., & Goedert, J. J. (1998). The influence of pregnancy on human immunodeficiency virus type 1 infection: Antepartum and postpartum changes in human immunodeficiency virus type 1 viral load. American journal of obstetrics and gynecology, 178(2), 355-359. https://doi.org/10.1016/S0002-9378(98)80025-2

Burns, DN, Landesman, S, Minkoff, H, Wright, DJ, Waters, D, Mitchell, RM, Rubinstein, A, Willoughby, A & Goedert, JJ 1998, 'The influence of pregnancy on human immunodeficiency virus type 1 infection: Antepartum and postpartum changes in human immunodeficiency virus type 1 viral load', American journal of obstetrics and gynecology, vol. 178, no. 2, pp. 355-359. https://doi.org/10.1016/S0002-9378(98)80025-2

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title = "The influence of pregnancy on human immunodeficiency virus type 1 infection: Antepartum and postpartum changes in human immunodeficiency virus type 1 viral load",

abstract = "OBJECTIVE: Our objective was to examine the influence of pregnancy on human immunodeficiency virus type 1 viral lead by measuring human immunodeficiency virus type 1 ribonucleic acid levels during pregnancy and post partum. STUDY DESIGN: One or more plasma or serum specimens obtained before and during the third trimester, and at 2, 12, and 24 months post partum were available for 160 human immunodeficiency virus type 1- seropositive women enrolled in the Mothers and Infants Cohort Study between January 1986 and January 1991. All specimens were frozen and stored at - 70°C until analyzed in batch for human immunodeficiency virus type 1 ribonucleic acid by polymerase chain reaction. A multivariate longitudinal random effects model was developed to examine changes in human immunodeficiency virus type 1 ribonucleic acid levels over time. RESULTS: Overall, human immunodeficiency virus type 1 ribonucleic acid levels rose significantly during the study period, particularly during the second year post partum (mean, 0.09 log per year; 95% confidence interval, 0.03 to 0.15 logs per year; p = 0.005). However, the mean slope during pregnancy was not significantly different from zero (p = 0.65). CONCLUSION: Pregnancy had little immediate effect on human immunodeficiency virus type l viral lead in most human immunodeficiency virus type 1-seropositive women.",

keywords = "Acquired immunodeficiency syndrome, Human immunodeficiency virus, Pregnancy, Ribonucleic acid, Virus",

author = "Burns, {D. N.} and S. Landesman and H. Minkoff and Wright, {D. J.} and D. Waters and Mitchell, {R. M.} and A. Rubinstein and A. Willoughby and Goedert, {J. J.}",

note = "Funding Information: From the Pediatric, Adolescent, and Maternal AIDS Branch, National Institute of Child Health and Human Development, National Institutes of Health, a the Department of Medicine, b and the Department of Obstetrics and Gynecology,c State University of New York Health Science Center, Westat, Inc., d SAIC, e the Department of Pediatrics, Albert Einstein College of Medicine, f and the Viral Epidemiology Branch, National Cancer Institute, National Institutes of Health.g Supported by grant RO-1-HD-25714 and contract NO-1-HD-8-2913 from the National Institute of Child Health and Human Development and contract NO-1-CP-61013 from the National Cancer Institute, Bethesda, Maryland. Receivedf or publication April 8, 1997; revised May 27, 1997; accepted September 8, 1997. Reprint requests: D. Burns, MD, Pediatric, Adolescent and Maternal AIDS Branch, National Institute of Child Health and Human Development, 6100 Executive Blvd., Suite 4B11, Rockville, MD 20892-7510. 6/1/85946",

year = "1998",

doi = "10.1016/S0002-9378(98)80025-2",

language = "English (US)",

volume = "178",

pages = "355--359",

journal = "American journal of obstetrics and gynecology",

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T1 - The influence of pregnancy on human immunodeficiency virus type 1 infection

T2 - Antepartum and postpartum changes in human immunodeficiency virus type 1 viral load

AU - Burns, D. N.

AU - Landesman, S.

AU - Minkoff, H.

AU - Wright, D. J.

AU - Waters, D.

AU - Mitchell, R. M.

AU - Rubinstein, A.

AU - Willoughby, A.

AU - Goedert, J. J.

N1 - Funding Information: From the Pediatric, Adolescent, and Maternal AIDS Branch, National Institute of Child Health and Human Development, National Institutes of Health, a the Department of Medicine, b and the Department of Obstetrics and Gynecology,c State University of New York Health Science Center, Westat, Inc., d SAIC, e the Department of Pediatrics, Albert Einstein College of Medicine, f and the Viral Epidemiology Branch, National Cancer Institute, National Institutes of Health.g Supported by grant RO-1-HD-25714 and contract NO-1-HD-8-2913 from the National Institute of Child Health and Human Development and contract NO-1-CP-61013 from the National Cancer Institute, Bethesda, Maryland. Receivedf or publication April 8, 1997; revised May 27, 1997; accepted September 8, 1997. Reprint requests: D. Burns, MD, Pediatric, Adolescent and Maternal AIDS Branch, National Institute of Child Health and Human Development, 6100 Executive Blvd., Suite 4B11, Rockville, MD 20892-7510. 6/1/85946

PY - 1998

Y1 - 1998

N2 - OBJECTIVE: Our objective was to examine the influence of pregnancy on human immunodeficiency virus type 1 viral lead by measuring human immunodeficiency virus type 1 ribonucleic acid levels during pregnancy and post partum. STUDY DESIGN: One or more plasma or serum specimens obtained before and during the third trimester, and at 2, 12, and 24 months post partum were available for 160 human immunodeficiency virus type 1- seropositive women enrolled in the Mothers and Infants Cohort Study between January 1986 and January 1991. All specimens were frozen and stored at - 70°C until analyzed in batch for human immunodeficiency virus type 1 ribonucleic acid by polymerase chain reaction. A multivariate longitudinal random effects model was developed to examine changes in human immunodeficiency virus type 1 ribonucleic acid levels over time. RESULTS: Overall, human immunodeficiency virus type 1 ribonucleic acid levels rose significantly during the study period, particularly during the second year post partum (mean, 0.09 log per year; 95% confidence interval, 0.03 to 0.15 logs per year; p = 0.005). However, the mean slope during pregnancy was not significantly different from zero (p = 0.65). CONCLUSION: Pregnancy had little immediate effect on human immunodeficiency virus type l viral lead in most human immunodeficiency virus type 1-seropositive women.

AB - OBJECTIVE: Our objective was to examine the influence of pregnancy on human immunodeficiency virus type 1 viral lead by measuring human immunodeficiency virus type 1 ribonucleic acid levels during pregnancy and post partum. STUDY DESIGN: One or more plasma or serum specimens obtained before and during the third trimester, and at 2, 12, and 24 months post partum were available for 160 human immunodeficiency virus type 1- seropositive women enrolled in the Mothers and Infants Cohort Study between January 1986 and January 1991. All specimens were frozen and stored at - 70°C until analyzed in batch for human immunodeficiency virus type 1 ribonucleic acid by polymerase chain reaction. A multivariate longitudinal random effects model was developed to examine changes in human immunodeficiency virus type 1 ribonucleic acid levels over time. RESULTS: Overall, human immunodeficiency virus type 1 ribonucleic acid levels rose significantly during the study period, particularly during the second year post partum (mean, 0.09 log per year; 95% confidence interval, 0.03 to 0.15 logs per year; p = 0.005). However, the mean slope during pregnancy was not significantly different from zero (p = 0.65). CONCLUSION: Pregnancy had little immediate effect on human immunodeficiency virus type l viral lead in most human immunodeficiency virus type 1-seropositive women.

KW - Acquired immunodeficiency syndrome

KW - Human immunodeficiency virus

KW - Pregnancy

KW - Ribonucleic acid

KW - Virus

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The influence of pregnancy on human immunodeficiency virus type 1 infection: Antepartum and postpartum changes in human immunodeficiency virus type 1 viral load

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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