Abstract
Objective: To investigate whether there is a difference in the ectopic/heterotopic pregnancy rate of blastocyst-stage frozen-thawed embryo transfers (FETs) compared with that of cleavage-stage FETs. Design: A retrospective cohort study. Setting: Not applicable. Patient(s): Women undergoing autologous FETs at either the blastocyst stage (n = 118,572) or the cleavage stage (n = 117,619), as reported to the Society for Assisted Reproductive Technology from 2004 to 2013. Intervention(s): None. Main Outcome Measure(s): Pregnancy outcomes, specifically ectopic pregnancy rates and heterotopic pregnancy rates. Result(s): Among those who became pregnant, there was a significantly lower incidence of ectopic/heterotopic pregnancies in blastocyst-stage FETs versus that in cleavage-stage FETs (0.8% vs. 1.1%). The differences in ectopic/heterotopic pregnancy rates remained statistically significant after controlling for confounders such as tubal factor infertility and number of embryos transferred. Conclusion(s): Blastocyst-stage FET was associated with a lower ectopic/heterotopic pregnancy rate compared with cleavage-stage FET.
Original language | English (US) |
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Pages (from-to) | 421-427 |
Number of pages | 7 |
Journal | F and S Reports |
Volume | 2 |
Issue number | 4 |
DOIs | |
State | Published - Dec 2021 |
Keywords
- Ectopic pregnancy
- blastocyst-stage FET
- cleavage-stage FET
- heterotopic pregnancy
ASJC Scopus subject areas
- Embryology
- Obstetrics and Gynecology
- Reproductive Medicine