@article{7fe1a886552f4a13b005b753d31e965d,
title = "The hippo signaling transducer TAZ regulates mammary gland morphogenesis and carcinogen-induced mammary tumorigenesis",
abstract = "Hippo signaling pathway is an evolutionarily conserved pathway that controls organ size by regulating cell proliferation, apoptosis and stem cell self-renewal. TAZ (transcriptional coactivator with the PDZ-binding motif) is a key downstream effector of the mammalian Hippo pathway. Here, using a transgenic mouse model with mammary-gland-specific expression of constitutively active TAZ, we found that TAZ induction in mammary epithelial cells was associated with an increase in mammary glandular size, which probably resulted from adipocyte hypertrophy. Consistent with its known oncogenic potential, we observed tumor formation in TAZ transgenic mice after administration of the carcinogen 7,12-dimethylbenzanthracene (DMBA) and demonstrated that tumorigenesis was reliant on the presence of TAZ. Our findings establish a previously unknown roles of TAZ in regulating both mammary gland morphogenesis as well as carcinogen-induced mammary tumor formation.",
author = "Denson, {Kayla E.} and Mussell, {Ashley L.} and He Shen and Alexander Truskinovsky and Nuo Yang and Natesh Parashurama and Yanmin Chen and Costa Frangou and Fajun Yang and Jianmin Zhang",
note = "Funding Information: We thank Dr. Kenneth W. Gross and Aimee B. Stablewski at the Gene Targeting and Transgenic Resource of RPCI for generating the TRE-TAZ4SA transgenic mice. We also thank Dr. Steven C. Pruitt at RPCI for kindly providing the pTRE-Tight plasmid and Dr. Yi Zhu at the UT Southwestern Medical Center for kindly sharing with us the ex vivo lipolysis and lipid clearance protocols. We thank Dr. Lester Kobzik for comments and critical reading of the manuscript. This work was supported by the Roswell Park Cancer Institute and National Cancer Institute (NCI) Grant #P30 CA016056, Roswell Park Alliance Foundation, National Cancer Institute (NCI) R21 CA179693, R01 CA207504 and the American Cancer Society Research Scholar Grant RSG-14-214-01-TBE (to J.Z.). Publisher Copyright: {\textcopyright} 2018 The Author(s).",
year = "2018",
month = dec,
day = "1",
doi = "10.1038/s41598-018-24712-5",
language = "English (US)",
volume = "8",
journal = "Scientific reports",
issn = "2045-2322",
publisher = "Nature Publishing Group",
number = "1",
}