The G protein connection: molecular basis of membrane association

Allen M. Spiegel, Peter S. Backlund, James E. Butrynski, Teresa L.Z. Jones, William F. Simonds

Research output: Contribution to journalArticlepeer-review

91 Scopus citations


Two distinct types of lipid modification, myristoylation and isoprenylation, are critical for membrane association of heterotrimeric G proteins. Elucidation of the molecular basis for G protein membrane association has important implications for understanding G protein structure and function, and is relevant to potential therapeutic approaches to AIDS and cancer.

Original languageEnglish (US)
Pages (from-to)338-341
Number of pages4
JournalTrends in Biochemical Sciences
Issue numberC
StatePublished - 1991
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology


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