TY - JOUR
T1 - The follicle-stimulating hormone receptor
T2 - A novel target in genitourinary malignancies
AU - Gartrell, Benjamin A.
AU - Tsao, Che kai
AU - Galsky, Matthew D.
PY - 2013/11
Y1 - 2013/11
N2 - Follicle-stimulating hormone (FSH) is a central hormone in mammalian reproductive biology. The FSH receptor (FSHR), which was previously believed to be expressed primarily in the ovary and testis, was recently found to be expressed in the tumor blood vessels of many solid tumor types, including prostate adenocarcinoma, urothelial carcinoma, and renal cell carcinoma. While the biologic significance of FSHR in tumor blood vessels has yet to be elucidated, FSHR may contribute to neoangiogenesis. FSHR has been reported to be expressed by prostate cancer cells and, thus, targeting FSHR in prostate cancer may be of particular utility. In this report, we discuss the finding of FSHR in tumor blood vessels and review the literature concerning FSHR in genitourinary malignancy. We also discuss the features that make FSHR an appealing target for therapeutic and imaging purposes and the potential utility of FSHR as a prognostic and/or predictive biomarker in genitourinary cancers.
AB - Follicle-stimulating hormone (FSH) is a central hormone in mammalian reproductive biology. The FSH receptor (FSHR), which was previously believed to be expressed primarily in the ovary and testis, was recently found to be expressed in the tumor blood vessels of many solid tumor types, including prostate adenocarcinoma, urothelial carcinoma, and renal cell carcinoma. While the biologic significance of FSHR in tumor blood vessels has yet to be elucidated, FSHR may contribute to neoangiogenesis. FSHR has been reported to be expressed by prostate cancer cells and, thus, targeting FSHR in prostate cancer may be of particular utility. In this report, we discuss the finding of FSHR in tumor blood vessels and review the literature concerning FSHR in genitourinary malignancy. We also discuss the features that make FSHR an appealing target for therapeutic and imaging purposes and the potential utility of FSHR as a prognostic and/or predictive biomarker in genitourinary cancers.
KW - Follicle-stimulating hormone receptor
KW - Neoangiogenesis
KW - Targeted therapeutics
UR - http://www.scopus.com/inward/record.url?scp=84886285021&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84886285021&partnerID=8YFLogxK
U2 - 10.1016/j.urolonc.2012.03.005
DO - 10.1016/j.urolonc.2012.03.005
M3 - Review article
C2 - 22513137
AN - SCOPUS:84886285021
SN - 1078-1439
VL - 31
SP - 1403
EP - 1407
JO - Urologic Oncology: Seminars and Original Investigations
JF - Urologic Oncology: Seminars and Original Investigations
IS - 8
ER -