TY - JOUR
T1 - The Extracellular RNA Communication Consortium
T2 - Establishing Foundational Knowledge and Technologies for Extracellular RNA Research
AU - The Extracellular RNA Communication Consortium
AU - Das, Saumya
AU - Abdel-Mageed, Asim B.
AU - Adamidi, Catherine
AU - Adelson, P. David
AU - Akat, Kemal M.
AU - Alsop, Eric
AU - Ansel, K. Mark
AU - Arango, Jorge
AU - Aronin, Neil
AU - Avsaroglu, Seda Kilinc
AU - Azizian, Azadeh
AU - Balaj, Leonora
AU - Ben-Dov, Iddo Z.
AU - Bertram, Karl
AU - Bitzer, Markus
AU - Blelloch, Robert
AU - Bogardus, Kimberly A.
AU - Breakefield, Xandra Owens
AU - Calin, George A.
AU - Carter, Bob S.
AU - Charest, Al
AU - Chen, Clark C.
AU - Chitnis, Tanuja
AU - Coffey, Robert J.
AU - Courtright-Lim, Amanda
AU - Datta, Amrita
AU - DeHoff, Peter
AU - Diacovo, Thomas G.
AU - Erle, David J.
AU - Etheridge, Alton
AU - Ferrer, Marc
AU - Franklin, Jeffrey L.
AU - Freedman, Jane E.
AU - Galas, David J.
AU - Galeev, Timur
AU - Gandhi, Roopali
AU - Garcia, Aitor
AU - Ghai, Vikas
AU - Ghiran, Ionita Calin
AU - Giraldez, Maria D.
AU - Goga, Andrei
AU - Gogakos, Tasos
AU - Goilav, Beatrice
AU - Gould, Stephen J.
AU - Guo, Peixuan
AU - Gupta, Mihir
AU - Hochberg, Fred
AU - Huang, Bo
AU - Putterman, Chaim
AU - Williams, Zev
N1 - Publisher Copyright:
© 2019 Elsevier Inc.
PY - 2019/4/4
Y1 - 2019/4/4
N2 - The Extracellular RNA Communication Consortium (ERCC) was launched to accelerate progress in the new field of extracellular RNA (exRNA) biology and to establish whether exRNAs and their carriers, including extracellular vesicles (EVs), can mediate intercellular communication and be utilized for clinical applications. Phase 1 of the ERCC focused on exRNA/EV biogenesis and function, discovery of exRNA biomarkers, development of exRNA/EV-based therapeutics, and construction of a robust set of reference exRNA profiles for a variety of biofluids. Here, we present progress by ERCC investigators in these areas, and we discuss collaborative projects directed at development of robust methods for EV/exRNA isolation and analysis and tools for sharing and computational analysis of exRNA profiling data. The Extracellular RNA Communication Consortium (ERCC) presents progress toward understanding the biology of extracellular RNAs and their use as biomarkers and therapeutics.
AB - The Extracellular RNA Communication Consortium (ERCC) was launched to accelerate progress in the new field of extracellular RNA (exRNA) biology and to establish whether exRNAs and their carriers, including extracellular vesicles (EVs), can mediate intercellular communication and be utilized for clinical applications. Phase 1 of the ERCC focused on exRNA/EV biogenesis and function, discovery of exRNA biomarkers, development of exRNA/EV-based therapeutics, and construction of a robust set of reference exRNA profiles for a variety of biofluids. Here, we present progress by ERCC investigators in these areas, and we discuss collaborative projects directed at development of robust methods for EV/exRNA isolation and analysis and tools for sharing and computational analysis of exRNA profiling data. The Extracellular RNA Communication Consortium (ERCC) presents progress toward understanding the biology of extracellular RNAs and their use as biomarkers and therapeutics.
UR - http://www.scopus.com/inward/record.url?scp=85063395528&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85063395528&partnerID=8YFLogxK
U2 - 10.1016/j.cell.2019.03.023
DO - 10.1016/j.cell.2019.03.023
M3 - Review article
C2 - 30951667
AN - SCOPUS:85063395528
SN - 0092-8674
VL - 177
SP - 231
EP - 242
JO - Cell
JF - Cell
IS - 2
ER -