The effects of manganese overexposure on brain health

Mahfuzur R. Miah, Omamuyovwi M. Ijomone, Comfort O.A. Okoh, Olayemi K. Ijomone, Grace T. Akingbade, Tao Ke, Bárbara Krum, Airton da Cunha Martins, Ayodele Akinyemi, Nicole Aranoff, Felix Alexandre Antunes Soares, Aaron B. Bowman, Michael Aschner

Research output: Contribution to journalReview articlepeer-review

78 Scopus citations


Manganese (Mn) is the twelfth most abundant element on the earth and an essential metal to human health. Mn is present at low concentrations in a variety of dietary sources, which provides adequate Mn content to sustain support various physiological processes in the human body. However, with the rise of Mn utility in a variety of industries, there is an increased risk of overexposure to this transition metal, which can have neurotoxic consequences. This risk includes occupational exposure of Mn to workers as well as overall increased Mn pollution affecting the general public. Here, we review exposure due to air pollution and inhalation in industrial settings; we also delve into the toxic effects of manganese on the brain such as oxidative stress, inflammatory response and transporter dysregulation. Additionally, we summarize current understandings underlying the mechanisms of Mn toxicity.

Original languageEnglish (US)
Article number104688
JournalNeurochemistry International
StatePublished - May 2020


  • Air pollution
  • Brain health
  • Manganese
  • Metal imbalance
  • Nervous system
  • Neurodegeneration
  • Neurotoxicity
  • Oxidative stress

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Cell Biology


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