The effects of manganese overexposure on brain health

Mahfuzur R. Miah; Omamuyovwi M. Ijomone; Comfort O.A. Okoh; Olayemi K. Ijomone; Grace T. Akingbade; Tao Ke; Bárbara Krum; Airton da Cunha Martins; Ayodele Akinyemi; Nicole Aranoff; Felix Alexandre Antunes Soares; Aaron B. Bowman; Michael Aschner

doi:10.1016/j.neuint.2020.104688

The effects of manganese overexposure on brain health

Mahfuzur R. Miah, Omamuyovwi M. Ijomone, Comfort O.A. Okoh, Olayemi K. Ijomone, Grace T. Akingbade, Tao Ke, Bárbara Krum, Airton da Cunha Martins, Ayodele Akinyemi, Nicole Aranoff, Felix Alexandre Antunes Soares, Aaron B. Bowman, Michael Aschner

Molecular Pharmacology

Research output: Contribution to journal › Review article › peer-review

72 Scopus citations

Abstract

Manganese (Mn) is the twelfth most abundant element on the earth and an essential metal to human health. Mn is present at low concentrations in a variety of dietary sources, which provides adequate Mn content to sustain support various physiological processes in the human body. However, with the rise of Mn utility in a variety of industries, there is an increased risk of overexposure to this transition metal, which can have neurotoxic consequences. This risk includes occupational exposure of Mn to workers as well as overall increased Mn pollution affecting the general public. Here, we review exposure due to air pollution and inhalation in industrial settings; we also delve into the toxic effects of manganese on the brain such as oxidative stress, inflammatory response and transporter dysregulation. Additionally, we summarize current understandings underlying the mechanisms of Mn toxicity.

Original language	English (US)
Article number	104688
Journal	Neurochemistry International
Volume	135
DOIs	https://doi.org/10.1016/j.neuint.2020.104688
State	Published - May 2020

Keywords

Air pollution
Brain health
Manganese
Metal imbalance
Nervous system
Neurodegeneration
Neurotoxicity
Oxidative stress

ASJC Scopus subject areas

Cellular and Molecular Neuroscience
Cell Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.neuint.2020.104688

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title = "The effects of manganese overexposure on brain health",

abstract = "Manganese (Mn) is the twelfth most abundant element on the earth and an essential metal to human health. Mn is present at low concentrations in a variety of dietary sources, which provides adequate Mn content to sustain support various physiological processes in the human body. However, with the rise of Mn utility in a variety of industries, there is an increased risk of overexposure to this transition metal, which can have neurotoxic consequences. This risk includes occupational exposure of Mn to workers as well as overall increased Mn pollution affecting the general public. Here, we review exposure due to air pollution and inhalation in industrial settings; we also delve into the toxic effects of manganese on the brain such as oxidative stress, inflammatory response and transporter dysregulation. Additionally, we summarize current understandings underlying the mechanisms of Mn toxicity.",

keywords = "Air pollution, Brain health, Manganese, Metal imbalance, Nervous system, Neurodegeneration, Neurotoxicity, Oxidative stress",

author = "Miah, {Mahfuzur R.} and Ijomone, {Omamuyovwi M.} and Okoh, {Comfort O.A.} and Ijomone, {Olayemi K.} and Akingbade, {Grace T.} and Tao Ke and B{\'a}rbara Krum and {da Cunha Martins}, Airton and Ayodele Akinyemi and Nicole Aranoff and {Antunes Soares}, {Felix Alexandre} and Bowman, {Aaron B.} and Michael Aschner",

note = "Publisher Copyright: {\textcopyright} 2020 Elsevier Ltd",

year = "2020",

month = may,

doi = "10.1016/j.neuint.2020.104688",

language = "English (US)",

volume = "135",

journal = "Neurochemistry International",

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T1 - The effects of manganese overexposure on brain health

AU - Miah, Mahfuzur R.

AU - Ijomone, Omamuyovwi M.

AU - Okoh, Comfort O.A.

AU - Ijomone, Olayemi K.

AU - Akingbade, Grace T.

AU - Ke, Tao

AU - Krum, Bárbara

AU - da Cunha Martins, Airton

AU - Akinyemi, Ayodele

AU - Aranoff, Nicole

AU - Antunes Soares, Felix Alexandre

AU - Bowman, Aaron B.

AU - Aschner, Michael

PY - 2020/5

Y1 - 2020/5

N2 - Manganese (Mn) is the twelfth most abundant element on the earth and an essential metal to human health. Mn is present at low concentrations in a variety of dietary sources, which provides adequate Mn content to sustain support various physiological processes in the human body. However, with the rise of Mn utility in a variety of industries, there is an increased risk of overexposure to this transition metal, which can have neurotoxic consequences. This risk includes occupational exposure of Mn to workers as well as overall increased Mn pollution affecting the general public. Here, we review exposure due to air pollution and inhalation in industrial settings; we also delve into the toxic effects of manganese on the brain such as oxidative stress, inflammatory response and transporter dysregulation. Additionally, we summarize current understandings underlying the mechanisms of Mn toxicity.

AB - Manganese (Mn) is the twelfth most abundant element on the earth and an essential metal to human health. Mn is present at low concentrations in a variety of dietary sources, which provides adequate Mn content to sustain support various physiological processes in the human body. However, with the rise of Mn utility in a variety of industries, there is an increased risk of overexposure to this transition metal, which can have neurotoxic consequences. This risk includes occupational exposure of Mn to workers as well as overall increased Mn pollution affecting the general public. Here, we review exposure due to air pollution and inhalation in industrial settings; we also delve into the toxic effects of manganese on the brain such as oxidative stress, inflammatory response and transporter dysregulation. Additionally, we summarize current understandings underlying the mechanisms of Mn toxicity.

KW - Air pollution

KW - Brain health

KW - Manganese

KW - Metal imbalance

KW - Nervous system

KW - Neurodegeneration

KW - Neurotoxicity

KW - Oxidative stress

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U2 - 10.1016/j.neuint.2020.104688

DO - 10.1016/j.neuint.2020.104688

M3 - Review article

C2 - 31972215

AN - SCOPUS:85078207481

SN - 0197-0186

VL - 135

JO - Neurochemistry International

JF - Neurochemistry International

M1 - 104688

ER -

The effects of manganese overexposure on brain health

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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