TY - JOUR
T1 - The effectiveness of opioid substitution treatments for patients with opioid dependence
T2 - A systematic review and multiple treatment comparison protocol
AU - Dennis, Brittany B.
AU - Naji, Leen
AU - Bawor, Monica
AU - Bonner, Ashley
AU - Varenbut, Michael
AU - Daiter, Jeff
AU - Plater, Carolyn
AU - Pare, Guillaume
AU - Marsh, David C.
AU - Worster, Andrew
AU - Desai, Dipika
AU - Samaan, Zainab
AU - Thabane, Lehana
N1 - Funding Information:
We report no competing interests for this investigation. This work was supported by CIHR Drug Safety and Effectiveness Network (DSEN) grant (Grant No. 126639). The funders had no role in study design and conduct of the study; collection, management, analysis, and interpretation of the data; and preparation, review, or approval of the manuscript.
Publisher Copyright:
© 2014 Dennis et al.; licensee BioMed Central Ltd.
PY - 2014/9/19
Y1 - 2014/9/19
N2 - Background: Opioids are psychoactive analgesic drugs prescribed for pain relief and palliative care. Due to their addictive potential, effort and vigilance in controlling prescriptions is needed to avoid misuse and dependence. Despite the effort, the prevalence of opioid use disorder continues to rise. Opioid substitution therapies are commonly used to treat opioid dependence; however, there is minimal consensus as to which therapy is most effective. Available treatments include methadone, heroin, buprenorphine, as well as naltrexone. This systematic review aims to assess and compare the effect of all available opioid substitution therapies on the treatment of opioid dependence. Methods/Design: The authors will search Medline, EMBASE, PubMed, PsycINFO, Web of Science, Cochrane Library, Cochrane Clinical Trials Registry, World Health Organization International Clinical Trials Registry Platform Search Portal, and the National Institutes for Health Clinical Trials Registry. The title, abstract, and full-text screening will be completed in duplicate. When appropriate, multiple treatment comparison Bayesian meta-analytic methods will be performed to deduce summary statistics estimating the effectiveness of all opioid substitution therapies in terms of retention and response to treatment (as measured through continued opioid abuse). Discussion: Using evidence gained from this systematic review, we anticipate disseminating an objective review of the current available literature on the effectiveness of all opioid substitution therapies for the treatment of opioid use disorder. The results of this systematic review are imperative to the further enhancement of clinical practice in addiction medicine. Systematic review registration: PROSPERO CRD42013006507.
AB - Background: Opioids are psychoactive analgesic drugs prescribed for pain relief and palliative care. Due to their addictive potential, effort and vigilance in controlling prescriptions is needed to avoid misuse and dependence. Despite the effort, the prevalence of opioid use disorder continues to rise. Opioid substitution therapies are commonly used to treat opioid dependence; however, there is minimal consensus as to which therapy is most effective. Available treatments include methadone, heroin, buprenorphine, as well as naltrexone. This systematic review aims to assess and compare the effect of all available opioid substitution therapies on the treatment of opioid dependence. Methods/Design: The authors will search Medline, EMBASE, PubMed, PsycINFO, Web of Science, Cochrane Library, Cochrane Clinical Trials Registry, World Health Organization International Clinical Trials Registry Platform Search Portal, and the National Institutes for Health Clinical Trials Registry. The title, abstract, and full-text screening will be completed in duplicate. When appropriate, multiple treatment comparison Bayesian meta-analytic methods will be performed to deduce summary statistics estimating the effectiveness of all opioid substitution therapies in terms of retention and response to treatment (as measured through continued opioid abuse). Discussion: Using evidence gained from this systematic review, we anticipate disseminating an objective review of the current available literature on the effectiveness of all opioid substitution therapies for the treatment of opioid use disorder. The results of this systematic review are imperative to the further enhancement of clinical practice in addiction medicine. Systematic review registration: PROSPERO CRD42013006507.
KW - Buprenorphine/naloxone
KW - Heroin
KW - Methadone
KW - Naltrexone
KW - Network meta-analysis
KW - Opioid dependence
KW - Opioid substitution therapies
KW - Systematic review
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U2 - 10.1186/2046-4053-3-105
DO - 10.1186/2046-4053-3-105
M3 - Article
C2 - 25239213
AN - SCOPUS:84926323602
SN - 2046-4053
VL - 3
JO - Systematic Reviews
JF - Systematic Reviews
IS - 1
M1 - 105
ER -