Abstract
There is clear evidence of the effects of sex and age on the prevalence of cardiovascular disease. We investigated the interactions of dietary omega ( n)-3 polyunsaturated fatty acids (PUFA), sex, and age on plasma lipids and lipoproteins in the offspring of C57BL/6 mice exposed to high, medium, or low n-3 PUFA at weaning and 16 weeks postweaning. There was an increase in plasma triglycerides from weaning to 16 weeks in male and female offspring however, the high n-3 PUFA group showed a reduction in triglycerides in both sexes at 16 weeks. High n-3 PUFA caused an increase in plasma LDL-cholesterol from weaning to 16 weeks in male offspring however, the LDL particle size was significantly larger in the high n-3 PUFA group. Plasma from male mice showed higher cholesterol efflux compared to females; high n-3 PUFA increased cholesterol efflux. Thus the effects of n-3 PUFA are age and sex dependent.
Original language | English (US) |
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Pages (from-to) | 39-47 |
Number of pages | 9 |
Journal | Prostaglandins Leukotrienes and Essential Fatty Acids |
Volume | 91 |
Issue number | 1-2 |
DOIs | |
State | Published - Jul 2014 |
Externally published | Yes |
Keywords
- Age
- Cholesterol efflux
- Lipids and lipoproteins
- N-3 PUFA
- Sex
ASJC Scopus subject areas
- Clinical Biochemistry
- Cell Biology