The effect of colchicine on guinea pig intestinal enzyme activity

Michael I. Cohen, Helen McNamara

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


The intestinal mucosal reaction to colchicine in guinea pigs as measured by sucrase, maltase, and gamma glutamyl transpeptidase activity is described. There is a significant fall in disaccharidase activity without alteration in the peptidase activity after colchicine administration. This suggests a specific response of the disaccharidase system rather than a generalized toxic mucosal effect of colchicine.

Original languageEnglish (US)
Pages (from-to)247-250
Number of pages4
JournalThe American Journal of Digestive Diseases
Issue number3
StatePublished - Mar 1 1970

ASJC Scopus subject areas

  • Gastroenterology


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