The effect of colchicine on guinea pig intestinal enzyme activity

Michael I. Cohen; Helen McNamara

doi:10.1007/BF02233455

The effect of colchicine on guinea pig intestinal enzyme activity

Michael I. Cohen, Helen McNamara

Pediatrics

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

The intestinal mucosal reaction to colchicine in guinea pigs as measured by sucrase, maltase, and gamma glutamyl transpeptidase activity is described. There is a significant fall in disaccharidase activity without alteration in the peptidase activity after colchicine administration. This suggests a specific response of the disaccharidase system rather than a generalized toxic mucosal effect of colchicine.

Original language	English (US)
Pages (from-to)	247-250
Number of pages	4
Journal	The American Journal of Digestive Diseases
Volume	15
Issue number	3
DOIs	https://doi.org/10.1007/BF02233455
State	Published - Mar 1 1970

ASJC Scopus subject areas

Gastroenterology

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10.1007/BF02233455

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title = "The effect of colchicine on guinea pig intestinal enzyme activity",

abstract = "The intestinal mucosal reaction to colchicine in guinea pigs as measured by sucrase, maltase, and gamma glutamyl transpeptidase activity is described. There is a significant fall in disaccharidase activity without alteration in the peptidase activity after colchicine administration. This suggests a specific response of the disaccharidase system rather than a generalized toxic mucosal effect of colchicine.",

author = "Cohen, {Michael I.} and Helen McNamara",

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N2 - The intestinal mucosal reaction to colchicine in guinea pigs as measured by sucrase, maltase, and gamma glutamyl transpeptidase activity is described. There is a significant fall in disaccharidase activity without alteration in the peptidase activity after colchicine administration. This suggests a specific response of the disaccharidase system rather than a generalized toxic mucosal effect of colchicine.

AB - The intestinal mucosal reaction to colchicine in guinea pigs as measured by sucrase, maltase, and gamma glutamyl transpeptidase activity is described. There is a significant fall in disaccharidase activity without alteration in the peptidase activity after colchicine administration. This suggests a specific response of the disaccharidase system rather than a generalized toxic mucosal effect of colchicine.

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The effect of colchicine on guinea pig intestinal enzyme activity

Abstract

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