@article{f2d75c394efb4cfba7ac08f132edfc7c,
title = "The effect of aphidicolin on adenovirus DNA synthesis",
abstract = "Aphidicolin inhibits adenovirus DNA replication in HeLa cells and in a cell-free,infected,nuclear extract in which viral DNA is elongated. The compound inhibits α DNA polymerase,extensively purified from HeLa cells, but has little or no effect on the β or γ DNA polymerases similarly purified. Aphidicolin does not affect thymidine uptake by cells nor does it break preformed DNA. The drug is not selective against viral DNA synthesis as it also inhibits DNA replication in uninfected cells. The inhibition by aphidicolin is reversible if the drug is removed within 18 hrs after addition to HeLa or Chinese Hamster ovary cells but the cells are irreversibly affected if the drug remains for 48 hours.",
author = "Mathew Longiaru and Ikeda, {Joh E.} and Zelda Jarkovsky and Horwitz, {Susan B.} and Marshall Horwitz",
note = "Funding Information: ACKNOWLEDGEMENTS: We are grateful to Jerard Hurwitz for helpful advice and critical reading of the manuscript. This work was supported by Public Health Service Grants CA*-11512, CA~15714, and CA^23187 from the National Cancer Institute; and Grants NP89K, VC 201 and CH86 from the American Cancer Society. M. L. was the recipient of support from a National Institutes of Health Training grant MB-9602, CA-09060; J. I. from the Cancer Research Center (National Cancer Institute P30 CA-13330; MSH and SBH are recipients of Irma T. Hirschl Trust Career Scientist Awards. The data in this paper are from a thesis to be submitted by M. L. in partial fulfillment for the degree of Doctor of Philosophy in the Sue Golding Graduate Division of Medical Sciences, Albert Einstein College of Medicine, Yeshiva University.",
year = "1979",
month = jul,
day = "25",
doi = "10.1093/nar/6.10.3369",
language = "English (US)",
volume = "6",
pages = "3369--3386",
journal = "Nucleic acids research",
issn = "0305-1048",
publisher = "Oxford University Press",
number = "10",
}